Results 71 to 80 of about 1,635,992 (296)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Surgical Approach to a Medial Epicondylectomy in Cubital Tunnel Syndrome

Plastic and Reconstructive Surgery, Global Open
Summary:. Cubital tunnel syndrome, a common neuropathy of the upper limb, presents with sensory and motor symptoms, impacting hand function and grip strength.
Abdus S. Burahee, MBChB, Liron S. Duraku, PhD, Rajive Jose, MD, Michiel J. Zuidam, PhD, Dominic M. Power, MB, BChir   +4 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Peripheral nerve injuries [PDF]

The American Journal of Surgery, 1932
Nerve injuries caused by medical interventions (Iatrogenic lesions) can complicate procedures and affect any part of the peripheral nervous system. Available data is fragmentary and little information is accessible on the overall incidence of iatrogenic nerve lesions that ranges from 1.5 to 15%.[1, 2] Major drawbacks are the limited number of patients ...
Anesti, Katerina, Caine, Paul
openaire   +3 more sources

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Repair Method for Complete High Ulnar Nerve Injury Based on Nerve Magnified Regeneration

, 2020
Wenquan Ding,1,* Xueyuan Li,1,* Jiadong Pan,1 Peixun Zhang,2 Shanqing Yin,1 Xianting Zhou,1 Junjie Li,1 Liping Wang,1,3 Xin Wang,1 Jianghui Dong1,3 1Department of Hand Surgery, Department of Plastic Reconstructive Surgery, Ningbo No.
Ding W, Li X, Pan J, Li J, Yin S, Dong J, Wang X, Zhou X, Zhang P, Wang L   +9 more
core  

Avoiding peripheral nerve injury in arterial interventions [PDF]

, 2019
Although peripheral nerve injuries secondary to angiography and endovascular interventions are uncommon and usually not permanent, they can result in significant functional impairment.
Frank Kuo, Jonathan Park, Kira Chow, Alice Chen, Matthew K. Walsworth   +4 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Learning and memory with neuropathic pain : impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Irmgard eTegeder, Vannoni, Elisabetta, Annett eHäussler, Irmgard Tegeder, Wolfer, David P., Elisabetta Vannoni, David P. Wolfer, Tegeder, Irmgard, Wolfer, David P, Elisabetta eVannoni, Annett Häussler, Häussler, Annett, Boris eAlbuquerque, Boris Albuquerque, Albuquerque, Boris, David P Wolfer, Wolfer, David Paul; id_orcid   +16 more
core   +1 more source

Flavonoids: a natural remedy in the prevention and management of diverse diseases

Frontiers in Medicine
BackgroundFlavonoids, which fall into the polyphenol family as secondary metabolites, can be widely found in traditional Chinese herbal medicines. Owing to their multi-target characteristics, low toxicity levels, and diverse sources, flavonoids have ...
Bo Yu, Jin Zhang, Mengxuan Zhu, Zongwu Li, Liqun Ren, Fan Zhang, Cuizhe Liu, Lin Zhang   +7 more
doaj   +1 more source