Results 61 to 70 of about 1,348,714 (289)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa   +7 more
wiley   +1 more source

Nerve-terminal And Schwann-cell Response After Nerve Injury In The Absence Of Nitric Oxide.

open access: yes, 2015
Dystrophic muscles show alterations in the dystrophin-glycoprotein complex and a lack of neuronal nitric oxide (NO) synthase. In mdx mice, presynaptic expression of neuronal NO synthase is decreased, suggesting that presynaptic signaling may be altered ...
Marques, Maria Julia   +3 more
core   +2 more sources

Brachial Plexus Nerve Trunk Recognition From Ultrasound Images: A Comparative Study of Deep Learning Models

open access: yesIEEE Access, 2022
Brachial plexus block is a common regional anesthesia method widely used in upper limb surgery. Nowadays, ultrasound-guided brachial plexus block has been extensively used in clinical anesthesia.
Dingcheng Tian   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Neural connectome of the ctenophore statocyst

open access: yeseLife
Ctenophores possess a unique gravity receptor (statocyst) in their aboral organ formed by four clusters of ciliated balancer cells that collectively support a statolith.
Kei Jokura   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of Structure on Function in Model Nerve Nets

open access: yesBiophysical Journal, 1974
A theoretical analysis has been made on the effect of the pattern of interneuronal connectivity in model nerve nets on the activity of these nets. Two types of nets have been investigated: one in which the likelihood of a connection between a given neuron and any other element in the net is given by a Poisson probability distribution, and a second type
Anninos, Photios A., Elul, Rafael
openaire   +2 more sources

Putative intermediates in the nerve cell differentiation pathway in hydra have properties of multipotent stem cells [PDF]

open access: yes, 1990
We have investigated the properties of nerve cell precursors in hydra by analyzing the differentiation and proliferation capacity of interstitial cells in the peduncle of Hydra oligactis, which is a region of active nerve cell differentiation.
Charles   +4 more
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Convolutional Neural Network Approaches in Median Nerve Morphological Assessment from Ultrasound Images

open access: yesJournal of Imaging
Ultrasound imaging has been used to investigate compression of the median nerve in carpal tunnel syndrome patients. Ultrasound imaging and the extraction of median nerve parameters from ultrasound images are crucial and are usually performed manually by ...
Shion Ando, Ping Yeap Loh
doaj   +1 more source

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