Results 41 to 50 of about 794,928 (281)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Deep Neural Network-Based Semantic Segmentation of Microvascular Decompression Images

Sensors, 2021
Image semantic segmentation has been applied more and more widely in the fields of satellite remote sensing, medical treatment, intelligent transportation, and virtual reality. However, in the medical field, the study of cerebral vessel and cranial nerve
Ruifeng Bai, Shan Jiang, Haijiang Sun, Yifan Yang, Guiju Li   +4 more
doaj   +1 more source

Brachial Plexus Nerve Trunk Segmentation Using Deep Learning: A Comparative Study with Doctors' Manual Segmentation [PDF]

, 2022
Ultrasound-guided nerve block anesthesia (UGNB) is a high-tech visual nerve block anesthesia method that can observe the target nerve and its surrounding structures, the puncture needle's advancement, and local anesthetics spread in real-time. The key in
Zhu, Binbin, Wang, Yu, Wang, Jianhua, Yao, Yudong, Wang, Jianlin, Gao, Bin, Tian, Dingcheng, Kong, Lingsi   +7 more
core   +1 more source

Automatic three-dimensional reconstruction of fascicles in peripheral nerves from histological images.

PLoS ONE, 2020
Computational studies can be used to support the development of peripheral nerve interfaces, but currently use simplified models of nerve anatomy, which may impact the applicability of simulation results.
Daniel Tovbis, Anne Agur, Jeremy P M Mogk, José Zariffa   +3 more
doaj   +1 more source

Multidimensional Characterisation of Time-dependent Image Data: A Case Study for the Peripheral Nervous System in Ageing Mice

Image Analysis and Stereology, 2021
Segmentation of µm-resolution image data of irregularly shaped objects poses challenges to existing segmentation algorithms. This is especially true, when imperfections like noise, uneven lightning or traces of sample preparation are present in the image
Matthias Weber, Thomas Wilhelm, Volker Schmidt   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Highly accurate Facial Nerve Segmentation Refinement from CBCT/CT Imaging using a Super Resolution Classification Approach.

, 2018
Facial nerve segmentation is of considerable importance for pre-operative planning of cochlear implantation. However, it is strongly influenced by the relatively low resolution of the cone-beam computed tomography (CBCT) images used in clinical practice.
Livia Barazzetti, Kate Gavaghan, Vimal Chandran, Weber, Stefan, Gerber, Kate, Ping Lu, Gerber, Nicolas, Chandran, Vimal, Mauricio Reyes, Reyes, Mauricio, Nicolas Gerber, Stefan Weber, Barazzetti, Livia, Lu, Ping, Reyes Aguirre, Mauricio Antonio   +14 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source