Results 61 to 70 of about 794,928 (281)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Hybrid Deep Neural Network for Brachial Plexus Nerve Segmentation in Ultrasound Images

, 2021
Ultrasound-guided regional anesthesia (UGRA) can replace general anesthesia (GA), improving pain control and recovery time. This method can be applied on the brachial plexus (BP) after clavicular surgeries.
Juul Van Boxtel, Vousten, Vincent R. J., Pluim, Josien P. W., Nastaran Mohammadian Rad, Boxtel, Juul P. A. van, Rad, Nastaran Mohammadian; id_orcid, Josien Pluim, Vincent Vousten   +7 more
core   +1 more source

A feasibility study of deep learning-based segmentation of the inferior alveolar nerve on magnetic resonance neurography

Scientific Reports
The inferior alveolar nerve (IAN) is the major sensory nerve innervating the mandibular region, and its automatic segmentation is crucial. It has been indirectly identified on the mandibular canal, which surrounds the IAN, using computed tomography (CT ...
Yoon Joo Choi, Sujeong Han, Chena Lee, Kug Jin Jeon, Haesung Oh, Sang-Sun Han, Jaesung Lee   +6 more
doaj   +1 more source

A novel workflow for 3D imaging and spatial analysis of nerves in bone

Bone Reports
Peripheral sensory and sympathetic nerves innervating bony tissues are of interest for their role in modulating bone function and responding to physiologic stimuli.
Allison L. Horenberg, Eric Z. Zeng, Yunke Ren, Tanishk Sinha, Emith Uyanwatte, Melia Matthews, Erica L. Scheller, Karl J. Lewis, Arvind P. Pathak, Warren L. Grayson   +9 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Facial Nerve Image Enhancement from CBCT using Supervised Learning Technique [PDF]

, 2015
Facial nerve segmentation plays an important role in surgical planning of cochlear implantation. Clinically available CBCT images are used for surgical planning.
Livia Barazzetti, Kate Gavaghan, Vimal Chandran, Weber, Stefan, Gerber, Kate, Ping Lu, Gerber, Nicolas, Chandran, Vimal, Mauricio Reyes, Reyes, Mauricio, Nicolas Gerber, Stefan Weber, Barazzetti, Livia, Lu, Ping   +13 more
core   +1 more source