Results 201 to 210 of about 3,905,054 (299)

Neurological tissue dissection techniques in mouse models for reproducible scientific results: Brain, spinal cord, cerebrospinal fluid, and sciatic nerve. [PDF]

PLoS One
Crew L, Seerley A, McElroy S, Panter AG.
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Targeting Endoplasmic Reticulum Stress With Exogenous GDNF Promotes Diabetic Corneal Epithelial and Neural Repair via PI3K/AKT Signaling. [PDF]

Invest Ophthalmol Vis Sci
Li H, Long J, Dai S, Han W, Zhang L, Chen B.   +5 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

NEMUCO: The In Vitro 4D NMJ as an Innovative Powerful Tool to Study Nerve and Muscle Cell-Cell Communication. [PDF]

Int J Mol Sci
Block K, Ziraldo G, Trautmann G, Furlan S, Singh A, Grosser S, Gutsmann M, Lorenzon P, Volpe P, Vida I, Blottner D, Salanova M.   +11 more
europepmc   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Corneal Nerve Injury and Regeneration: Mechanisms, Clinical Consequences, and Emerging Therapeutic Strategies. [PDF]

Drugs
Shadmani A, Galor A, Esmaeilkhanian H, Kostic M.   +3 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Extracellular vesicle-mediated restraint of hepatic CD74-NF-κB repairs diabetic neuropathy. [PDF]

Sci Adv
Yang H, Miao Y, Meng P, Niu J, Xi J, Zou Z, Hei Y, Zhao J, Luo Q, Huang S, Hu M, Zhang L, Baskys A, Wang Y, Li X, Long Q.   +15 more
europepmc   +1 more source

Neuroimmune Interactions in Chronic Pain and Neuroinflammation: Peripheral Nerve Injury, Neuroimmune Mechanisms, and Therapeutic Recovery. [PDF]

Biomolecules
Anwar AI, Jenkins LG, Branch BJ, Cassagne GA, Daigle GM, Levin MJ, Yaray O, Crosby SD, Kaye AD.   +8 more
europepmc   +1 more source