Results 201 to 210 of about 3,683,030 (295)

Revolutionizing the understanding of acupoint biology and acupuncture mechanisms through spatial omics: current perspectives and future directions. [PDF]

Front Med (Lausanne)
Guo X, Cao J, Su T, Ding X, Chen A, Kosgei BK, Zhang D, Wang F, Luo P.   +8 more
europepmc   +1 more source

Lipopolysaccharide-mediated macrophage polarization, conserved pathogenesis, and implications for peripheral neuropathy: a systematic review. [PDF]

Inflamm Res
Elson L, Eijkelkamp N, Coert JH.
europepmc   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Wnt/β-Catenin Signaling in Diabetic Complications: Mechanisms and Therapeutic Potential. [PDF]

Diabetes Metab Syndr Obes
Liu X, Liu Y, Zhang Y, Cao Z, Guo Q, Ji H, Liu D.   +6 more
europepmc   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Synergistic integration of flexible bioelectroactive nanofibrous conduits and electrical stimulation for accelerated peripheral nerve regeneration. [PDF]

Mater Today Bio
Cheng R, Li M, Wang J, Han L, Cui W, Xi Y, Guo L, Luo Y, Wang R, Sang S.   +9 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis. [PDF]

Sci Adv
Buchanan CN, Lee J, Matoo S, Headen JA, Honoree MC, Conway M, Thompson LF, Smith TP, McKay A, Tosadori C, Dalla Costa I, Lopez De Leon M, Thames E, Perrone-Bizzozero N, Kalinski AL, Welshhans K, Vaughn LS, Twiss JL.   +17 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

The evolving landscape of minimally invasive procedures in musculoskeletal diseases-part I. [PDF]

Front Med (Lausanne)
Saraiva F, Naredo E.
europepmc   +1 more source