Results 101 to 110 of about 2,814,068 (394)

Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases

Cell & Bioscience, 2020
Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity.
Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying [PDF]

, 2013
In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials.
A Calixto, A Singson, AC Gerlach, Cavita K. Chotoo, CC Mello, CI Bargmann, Cliff J. Luke, CM Fanger, CT Bond, D Fernández de Sevilla, Daniel C. Devor, ER Sawin, F Simmer, Gary A. Silverman, GM Herrera, IA Bany, J Kim, J Kyte, J Wolfart, JE Mendel, JG White, Jill C Bettinger, JJ Moresco, JP Adelman, JT Walter, KS Thorneloe, L Ségalat, M Dimitriadi, M Köhler, M Stocker, M Szatanik, M Zhang, MJ Miller, MR Klass, MR Koelle, MS Taylor, N Ringstad, PL Larsen, RM Empson, S Brenner, S Brähler, SE Bowden, TM Ishii, VG Shakkottai, WJ Joiner   +44 more
core   +3 more sources

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

Diagnosis of Alzheimer's disease by using biological markers in posterior cortical atrophy

Неврология, нейропсихиатрия, психосоматика
The use of biological markers for Alzheimer's disease (AD) allows diagnosis at the stage of moderate cognitive impairment and atypical course of the disease.
D. A. Grishina, N. A. Khayalieva, V. V. Grinyuk, A. Yu. Tyurina   +3 more
doaj   +1 more source

The Sympathetic Nervous System in Disease [PDF]

The Journal of Nervous and Mental Disease, 1922
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openaire   +1 more source

Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

Brain and Behavior, 2020
Leonurus japonicus Houtt., a traditional Chinese herbal medicine, is often used as a gynecological medicine with the effect of promoting blood circulation, regulating menstruation, clearing heat, and detoxificating.
Lu Huang, Ding-Qiao Xu, Yan-Yan Chen, S. Yue, Yu-Ping Tang   +4 more
semanticscholar   +1 more source

NMDAR‐Antibody Encephalitis Diagnosed With Primary Central Nervous System Lymphoma: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT N‐methyl‐D‐aspartate receptor‐antibody encephalitis (NMDAR encephalitis) is one of the most common forms of autoimmune encephalitis, with a paraneoplastic relationship described in approximately 38%. Primary central nervous system lymphoma (PCNSL) is a rare hematologic malignancy that is not often considered as the underlying neoplasm in this ...
Soo Hyun Ahn, Cynthea Prima, Tae Min Kim, Soon‐Tae Lee, Kon Chu   +4 more
wiley   +1 more source

Drug therapy for chronic musculoskeletal pain syndromes: the concept of adjuvant analgesics and the prospect of its implementation

Неврология, нейропсихиатрия, психосоматика, 2020
Treatment for pain syndromes is one of the most relevant areas of modern medicine, which is of high social, economic and, individual importance. One of the most difficult questions is therapy for chronic pain (CP).
S. A. Zhivolupov, I. V. Litvinenko, I. N. Samartsev, N. A. Rashidov, A. Yu. Kravchuk, A. N. Barinov   +5 more
doaj   +1 more source