Results 101 to 110 of about 2,663,952 (341)

Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseases [PDF]

, 2022
Weipeng Shi, Jing Zhang, Shang Zhen, Yingze Zhang, Yanzhi Xia, Haitao Fu, Tengbo Yu   +6 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Quality of Life and the Degree of Disease Acceptance In Patients with Spinocerebellar Ataxia

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2018
Introduction. Spinocerebellar ataxias (SCA) belong to a group of rare genetic diseases. They are characterized by the multiplicity of symptoms, of which the most characteristic is limb ataxia and dysarthria.
Magdalena Kazimierska-Zając, Robert Dymarek, Joanna Rosińczuk   +2 more
doaj   +1 more source

A review on recent advances on nobiletin in central and peripheral nervous system diseases [PDF]

, 2023
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding   +3 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Early Therapeutic Intervention in a Child with Beckwith–Wiedemann Syndrome in Inpatient and Outpatient Conditions — Case Report

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2019
Introduction. The Beckwith–Wiedemann syndrome (BWS) is a rare disorder characterized by a wide spectrum of symptoms i.a. umbilical hernia or omphalocele, macroglossia and above-average pre/postnatal growth (macrosomia). Aim. To present a case report of a
Teresa Kaczan, Robert Śmigiel, Magdalena Kazimierska-Zając, Robert Dymarek, Joanna Rosińczuk   +4 more
doaj   +1 more source

Research progress on adenosine in central nervous system diseases

CNS Neuroscience & Therapeutics, 2019
As an endogenous neuroprotectant agent, adenosine is extensively distributed and is particularly abundant in the central nervous system (CNS). Under physiological conditions, the concentration of adenosine is low intra‐ and extracellularly, but increases
Yingjiao Liu, Jiao Chen, Xun Li, Xin Zhou, Yaomei Hu, Shi-Feng Chu, Ye Peng, N. Chen   +7 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Biological markers of Alzheimer's disease in cerebrospinal fluid: clinical and laboratory comparisons

Неврология, нейропсихиатрия, психосоматика
Diagnostic hypothesis of Alzheimer's disease (AD) is based on the typical clinical picture of the disease and the exclusion of other diseases manifesting by cognitive and behavioural disorders by MRI scans of the brain and laboratory tests.
K. V. Shevtsova, D. O. Rozhkov, D. A. Grishina, V. V. Grinyuk, V. V. Zakharov, N. M. Kashakanova, N. N. Koberskaya, O. V. Kosivtsova, A. B. Lokshina, Yu. A. Starchina, A. Yu. Tyurina, A. Yu. Fedorova, V. A. Parfenov   +12 more
doaj   +1 more source