Results 91 to 100 of about 20,086,433 (308)

Identifying Common Genes, Cell Types and Brain Regions Between Diseases of the Nervous System

, 2019
Background: Diseases of the nervous system are widely considered to be caused by genetic mutations, and they have been shown to share pathogenic genes. Discovering the shared mechanisms of these diseases is useful for designing common treatments. Method:
Wang, Z, Qi, M, Lin, T, Liu, W, Yang, Y, Zhao, H, Yang, X, Fan, S, Xie, Z, Chen, K, Yan, Y, Zhang, L, Lin, X   +12 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Early Therapeutic Intervention in a Child with Beckwith–Wiedemann Syndrome in Inpatient and Outpatient Conditions — Case Report

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2019
Introduction. The Beckwith–Wiedemann syndrome (BWS) is a rare disorder characterized by a wide spectrum of symptoms i.a. umbilical hernia or omphalocele, macroglossia and above-average pre/postnatal growth (macrosomia). Aim. To present a case report of a
Teresa Kaczan, Robert Śmigiel, Magdalena Kazimierska-Zając, Robert Dymarek, Joanna Rosińczuk   +4 more
doaj   +1 more source

The peripheral nervous system and the pathogenesis of prion diseases. [PDF]

, 2004
Prion diseases are inevitably fatal neurodegenerative conditions which affect humans and a wide variety of animals. Unlike other protein aggregation diseases such as Alzheimer's, Parkinson's, and polyglutamine repeat diseases, prion diseases are unique ...
Giger, O, Glatzel, M, Braun, N, Aguzzi, A; https://orcid.org/   +3 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Biological markers of Alzheimer's disease in cerebrospinal fluid: clinical and laboratory comparisons

Неврология, нейропсихиатрия, психосоматика
Diagnostic hypothesis of Alzheimer's disease (AD) is based on the typical clinical picture of the disease and the exclusion of other diseases manifesting by cognitive and behavioural disorders by MRI scans of the brain and laboratory tests.
K. V. Shevtsova, D. O. Rozhkov, D. A. Grishina, V. V. Grinyuk, V. V. Zakharov, N. M. Kashakanova, N. N. Koberskaya, O. V. Kosivtsova, A. B. Lokshina, Yu. A. Starchina, A. Yu. Tyurina, A. Yu. Fedorova, V. A. Parfenov   +12 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Neurologopedic Correlates of Cognitive Ageing and Dementia

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2016
Introduction. Aging is the subject of interest of many fields of science. Equal place of neurologopedic studies do not raise doubts today — patients followed for deterioration not only of elementary cognitive functions as memory, perception and attention,
Joanna Rosińczuk, Magdalena Kazimierska-Zając, Robert Dymarek   +2 more
doaj   +1 more source

Drugs and the somatic nervous system [PDF]

, 2012
Drugs and the somatic nervous system\ud 8.1 The somatic nervous system\ud 8.2 Anticholinesterases\ud 8.3 Neuromuscular blockers\ud 8.4 ...
Doggrell, Sheila
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source