Results 91 to 100 of about 1,154,997 (309)

Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway

Scientific Reports, 2017
The RAS signaling pathway is hyperactive in malignant glioma due to overexpression and/or increased activity. A previous study identified that RASD1, a member of the RAS superfamily of small G-proteins, is a significantly dysregulated gene in ...
Shangfeng Gao, Lei Jin, Guangping Liu, Peng Wang, Zonghan Sun, Yujia Cao, Hengliang Shi, Xuejiao Liu, Qiong Shi, Xiuping Zhou, Rutong Yu   +10 more
doaj   +1 more source

EXHAUSTION DISEASES OF THE NERVOUS SYSTEM [PDF]

The Journal of Nervous and Mental Disease, 1905
n ...
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MicroRNAs in prion diseases [PDF]

, 2016
MicroRNAs (miRNAs) encompass a class of small RNA molecules (18-22 nucleotides) able to regulate gene expression posttranscriptionally, controlling virtually all processes in the cell in an unforeseen new manner.
Pereira, Tiago Campos, Zimbardi, Daniela [UNESP]   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

Journal of Experimental & Clinical Cancer Research, 2017
Background Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients.
Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu, Xuejiao Liu   +8 more
doaj   +1 more source

The Diseases of the Sympathetic Nervous System [PDF]

The American Journal of the Medical Sciences, 1880
n ...
openaire   +1 more source

Functions and effects of creatine in the central nervous system [PDF]

, 2008
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at ...
Schlattner, Uwe, Robert H. Andres, Uwe Schlattner, Hans Rudolf Widmer, Andres, Robert, H., Widmer, Hans Rudolf, Andres, Robert H, Wallimann, Theo, Theo Wallimann, Ducray, Angélique, Angélique D. Ducray, Ducray, Angélique, D.   +11 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source