Results 311 to 320 of about 1,893,805 (368)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Rare Earth Element Content in Hair Samples of Children Living in the Vicinity of the Kola Peninsula Mining Site and Nervous System Diseases. [PDF]

Biology (Basel)
Belisheva NK, Drogobuzhskaya SV.
europepmc   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

The PNS Nurse Program: A Health Care Support Concept for Patients With Immune-Mediated Peripheral Nervous System Diseases. [PDF]

Neurol Clin Pract
Pawlitzki M, Gasis M, Masanneck L, Meuth SG, Ruck T.   +4 more
europepmc   +1 more source

The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases. [PDF]

Mol Neurobiol
Papageorgakopoulou MA, Bania A, Lagogianni IA, Birmpas K, Assimakopoulou M.   +4 more
europepmc   +1 more source

Current progression in application of extracellular vesicles in central nervous system diseases. [PDF]

Eur J Med Res
Zhang XM, Huang J, Ni XY, Zhu HR, Huang ZX, Ding S, Yang XY, Tan YD, Chen JF, Cai JH.   +9 more
europepmc   +1 more source

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine. [PDF]

Adv Sci (Weinh)
Li J, Long Q, Ding H, Wang Y, Luo D, Li Z, Zhang W.   +6 more
europepmc   +1 more source

Advances in molecular mechanisms and therapeutic strategies for central nervous system diseases based on gut microbiota imbalance. [PDF]

J Adv Res
Tao W, Zhang Y, Wang B, Nie S, Fang L, Xiao J, Wu Y.   +6 more
europepmc   +1 more source