Results 61 to 70 of about 1,058,449 (296)

High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

Journal of Experimental & Clinical Cancer Research, 2017
Background Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients.
Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu, Xuejiao Liu   +8 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Quality of Life and the Degree of Disease Acceptance In Patients with Spinocerebellar Ataxia

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2018
Introduction. Spinocerebellar ataxias (SCA) belong to a group of rare genetic diseases. They are characterized by the multiplicity of symptoms, of which the most characteristic is limb ataxia and dysarthria.
Magdalena Kazimierska-Zając, Robert Dymarek, Joanna Rosińczuk   +2 more
doaj   +1 more source

Craniospinal irradiation for respiratory failure secondary to central nervous system Erdheim-Chester disease [PDF]

, 2022
Rahul N. Prasad, Peter Kobalka, Haley K. Perlow, Daniel M. Prevedello, Dukagjin Blakaj, Raju R. Raval, Joshua D. Palmer   +6 more
openalex   +1 more source

Diseases of the Nervous System [PDF]

Annual Review of Medicine, 1957
R A, FISHMAN, H H, MERRITT
openaire   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Early Therapeutic Intervention in a Child with Beckwith–Wiedemann Syndrome in Inpatient and Outpatient Conditions — Case Report

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2019
Introduction. The Beckwith–Wiedemann syndrome (BWS) is a rare disorder characterized by a wide spectrum of symptoms i.a. umbilical hernia or omphalocele, macroglossia and above-average pre/postnatal growth (macrosomia). Aim. To present a case report of a
Teresa Kaczan, Robert Śmigiel, Magdalena Kazimierska-Zając, Robert Dymarek, Joanna Rosińczuk   +4 more
doaj   +1 more source

Complete remission of central nervous system manifestations of IgG4-related disease with rituximab – a case report [PDF]

, 2023
Aleksi J. Sihvonen, Sini M. Laakso, Olli Tynninen, Heikki Saaren‐Seppälä, Mervi Löfberg   +4 more
openalex   +1 more source