Results 51 to 60 of about 20,086,433 (308)
Frontiers in Oncology, 2021 Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic
Xu Zhang +16 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
I.—DISEASES OF THE NERVOUS SYSTEM
The Journal of Nervous and Mental Disease, 1876 n ...
openaire +1 more source
Nervous system diseases comorbid to psoriasis [PDF]
, 2016 The information about the cormorbid pathology in patients with skin and nervous systems diseases is summarized on the base of Russian and foreign scientific literature.
Fisun A.V. +6 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases [PDF]
, 2019 Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to ...
Ling, King Hwa +6 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Notes on diseases of the nervous system
, 1886 NOTES ON DISEASES OF THE NERVOUS SYSTEM Notes on diseases of the nervous system (1) (-
Gowers, W. R.
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npj Precision OncologyPCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin +9 more
doaj +1 more source
Diagnosis of Alzheimer's disease by using biological markers in posterior cortical atrophy
Неврология, нейропсихиатрия, психосоматикаThe use of biological markers for Alzheimer's disease (AD) allows diagnosis at the stage of moderate cognitive impairment and atypical course of the disease.
D. A. Grishina +3 more
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