Results 61 to 70 of about 20,086,433 (308)

GYMNASTICS IN DISEASES OF THE NERVOUS SYSTEM [PDF]

The Journal of Nervous and Mental Disease, 1891
n ...
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Concentration of immunoglobulin free light chains in cerebrospinal fluid in the diagnosis of multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Objective: to determine the sensitivity and specificity of method of determining the concentration of immunoglobulin free light chains (FLCs) in cerebrospinal fluid (CSF) in the diagnosis and differential diagnosis of multiple sclerosis (MS).Material and
Sh. R. Nabiev, S. A. Dzhukkaeva, M. Sh. Asvedov, D. E. Prokhorov, E. V. Popova, V. V. Grinyuk, P. R. Magomadova, A. R. Apevalova, O. N. Voskresenskaya   +8 more
doaj   +1 more source

Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography

Communications Biology, 2023
Full-field optical coherence tomography (FFOCT) can be used for the visualization of the myenteric plexus network and individual myenteric ganglia cells in situ, showing that FFOCT is a suitable method to image enteric nervous system activity.
Tony Durand, Perrine Paul-Gilloteaux, Michalina Gora, Lara Laboudie, Emmanuel Coron, Isabelle Neveu, Michel Neunlist, Philippe Naveilhan   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Drug therapy for chronic musculoskeletal pain syndromes: the concept of adjuvant analgesics and the prospect of its implementation

Неврология, нейропсихиатрия, психосоматика, 2020
Treatment for pain syndromes is one of the most relevant areas of modern medicine, which is of high social, economic and, individual importance. One of the most difficult questions is therapy for chronic pain (CP).
S. A. Zhivolupov, I. V. Litvinenko, I. N. Samartsev, N. A. Rashidov, A. Yu. Kravchuk, A. N. Barinov   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The central vein sign in the diagnosis of multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Objective: to determine the specificity and sensitivity of the central vein sign (CVS) for the diagnosis of multiple sclerosis (MS). Material and methods. We analyzed 76 patients.
Sh. R. Nabiev, S. A. Dzhukkaeva, M. Sh. Asvedov, O. N. Voskresenskaya   +3 more
doaj   +1 more source

The Quality of Life in Patients After Surgical Treatment of a Lumbar Disc Herniation — a Preliminary Study

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2017
Introduction. Herniated intervertebral disc is a disease that is one of the main causes of sciatica and severe, sharp back pain and usually concerns adults aged 35 to 50 years. Aim.
Joanna Rosińczuk, Aleksandra Pytel, Małgorzata Miksiewicz, Aleksandra Kołtuniuk   +3 more
doaj   +1 more source

MicroRNA and Diseases of the Nervous System [PDF]

Neurosurgery, 2011
The recent discovery of microRNAs (miRNAs) has caused the traditional central dogma of molecular biology to be rewritten. miRNAs are small, noncoding pieces of ribonucleic acid that exert control over gene expression at the posttranscriptional level. They appear to play important roles in the normal development and functioning of the nervous system and
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