Results 41 to 50 of about 163,570 (248)

Effects of Tetrodotoxin on the Mammalian Cardiovascular System

Marine Drugs, 2010
The human genome encodes nine functional voltage-gated Na+ channels. Three of them, namely Nav1.5, Nav1.8, and Nav1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC50 ≥ 1 μM).
Thomas Zimmer
doaj   +1 more source

生命維持にかかわる生理現象を介した人間 : ロボットのコミュニケーションと身体情動モデルの設計 [PDF]

, 2018
関西大学In this dissertation, we focus on physiological phenomena of robots as the expressive modality of their inner states and discuss the effectiveness of a robot expressing physiological phenomena, which are indispensable for living.
Yoshida Naoto, 吉田 直人
core   +1 more source

Rhythmic dynamics and synchronization via dimensionality reduction : application to human gait [PDF]

, 2010
Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis.
A Arenas, A Babloyantz, A Bezerianos, A Brovelli, A Goldberger, A Pikovsky, A Tarca, A Wolf, B Cazelles, C Guy, C Haurie, C Peng, D Gates, D Luchinsky, E Bullmore, G Lee, G Rustici, H Abarbanel, H Kang, H Kantz, J Amigó, J Amigó, J Amigó, J Dingwell, J Dingwell, J Dingwell, J Hausdorff, J Hausdorff, J Marchini, J Zhang, J Zhang, J Zhang, Jianfeng Feng, Jie Zhang, Jürgen Kurths, K Chon, K Friston, K Friston, K Worsley, K Zhang, K Zhang, Kai Zhang, L Glass, L Kocarev, L Lacasa, L Olsen, L Pecora, M Belkin, M Kamiński, M Little, M Rosenblum, M Small, M Small, M Small, Michael Small, N Marwan, N Marwan, P Grassberger, R Bartsch, R Donner, R Donner, R Edwards, R Quiroga, S Guo, S Roweis, S Schiff, S Wichert, T Ge, W Lin, W Lin, Y Yang   +70 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Understanding Multicellularity: The Functional Organization of the Intercellular Space [PDF]

, 2019
The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration,
Bich, Leonardo, Moreau, Jean-Francois, Pradeu, Thomas   +2 more
core   +10 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Dysfunctional HCN ion channels in neurological diseases

Frontiers in Cellular Neuroscience, 2015
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems.
Jacopo C. DiFrancesco, Jacopo C. DiFrancesco, Dario eDiFrancesco   +2 more
doaj   +1 more source

DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption

Advanced Functional Materials, EarlyView.
The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim, Dai‐Hwan Kim, Priyannth R. Sundharbaabu, Chae Yeon Lee, Jina Bae, Jiyu Hyun, Young‐Ju Jang, Haeni Kim, Min‐Ho Hong, Juewen Liu, Tobias Fey, Suk Ho Bhang, Jun Hyuk Heo, Jung Heon Lee   +13 more
wiley   +1 more source