Results 171 to 180 of about 1,308,166 (292)

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage. [PDF]

Cell Death Dis
Sadamori K, Hiraiwa M, Horie T, Tokumura K, Fukasawa K, Sahashi K, Hayashida S, Kubo T, Yoshimoto M, Tsuji S, Ishigaki Y, Katsuno M, Hinoi E.   +12 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

1 A primer on the user-centred design of work procedures to improve healthcare performance

BMJ Open Quality, 2021
Paul Bowie, Gill Smith
doaj   +1 more source

Neutrophil-mediated delivery of curcumin-loaded manganese-doped zeolitic imidazolate framework-8 nanozymes for pulmonary arterial hypertension. [PDF]

J Nanobiotechnology
Dai C, Li X, Chu TS, Wan YP, Ge JJ.
europepmc   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

Bioactive Nanoemulsions for Enhancing Sausage and Meat Patty Shelf-Life. [PDF]

Foods
Pereira AG, Perez-Vazquez A, Barciela P, Jorge AOS, Yuksek EN, Nogueira-Marques R, Seyyedi-Mansour S, Prieto MA.   +7 more
europepmc   +1 more source

Volcano‐Inspired Dual‐Carbon Network Aerogel for High‐Performance Solar Evaporation With Edge‐Directed Salt Crystallization and Recovery

Advanced Science, EarlyView.
A volcano‐inspired dual‐carbon aerogel featuring hierarchical conduits and an outer carbon‐fiber shell directs rapid water transport, confines heat, and enables directional salt migration. Radial temperature gradients in the conical structure trigger Marangoni‐driven edge‐localized salt crystallization while maintaining an unobstructed photothermal ...
Shuyue Feng, Yongpeng Wang, Mengzhu Liu, Xin Wang, Tao Jia, Haibo Zhang, Haoyue Wu, Yuan Xu, Linghui Kong   +8 more
wiley   +1 more source

Long-term culture of patient-derived pheochromocytoma organoids. [PDF]

Front Endocrinol (Lausanne)
van den Berg MF, Timmermans-Sprang EPM, Zethof J, Kusters B, Olthaar A, van Herwaarden AE, van Wolferen ME, Timmers HJLM, Kooistra HS, Dona M, Galac S.   +10 more
europepmc   +1 more source