Results 51 to 60 of about 1,308,166 (292)

Ne, Ne Olmuş, Şimdi Ne Olacak

Türk Kütüphaneciliği, 2014
This studyis thetranslation ofthesection"What, so what, nowwhat"inthebook titled"Evidence-based Librarianship: casestudies andactive learning exercises”.The translation ofthesectiontitled"Evidence-basedlibrarianshipDown Under: improving a nation's resource­sharing" in the same book waspreviously made again forthe Journal ...
DEMİR, Güler, GÜNEŞ, Ayşenur
openaire   +2 more sources

A survey of factors influencing career preference in new-entrant and exiting medical students from four UK medical schools [PDF]

, 2014
Our thanks to Professor Gillian Needham and Dr Murray Lough for their encouragement and support, and their comments on an earlier draft of this manuscript.
Anthony, Michael, Cleland, Jennifer A, Johnston, Peter W, Khan, Nadir, Scott, Neil W   +4 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Gamma Radiation by Neutralino Stars [PDF]

, 1997
A new model of gamma radiation (GR) generated by neutralino annihilation in neutralino stars (NeS) is proposed. Diffuse Galactic and extragalactic GR is calculated for this model and is shown to be in a reasonable agreement with observations. The point
A.V. Gurevich, Alcock, Berezinsky, Bignami, Botino, Farrar, Fichtel, Gurevich, Gurevich, Gurevich, Gurevich, Gurevich, Gurevich, Gurevich, Gurevich, K.P. Zybin, Ostraiker, Roskowski, Thompson   +18 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Otel logosu ne söyler? Tüketiciler ne algılar?

Journal of Tourism Theory and Research, 2019
Bu araştırmanın temel amacı, otel işletmelerinin logolarını tasarlarken hedeflerini ve bu logoların tüketiciler üzerinde oluşturduğu algıları belirlemek ve logonun vermiş olduğu mesajı otel yöneticileri ile tüketiciler açısından karşılaştırarak ortaya koymaktır. Bu çalışmada nitel araştırma yöntemi kullanılmıştır.
Şirvan Şen DEMİR, Erge TÜR
openaire   +5 more sources

Efficient Mobile Data Collection with Mobile Collect [PDF]

, 2012
WISENET (NES ...
Hassanzadeh, Navid, Hermans, Frederik, Landsiedel, Olaf, Rensfelt, Olof, Voigt, Thiemo   +4 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source