Results 21 to 30 of about 166,869 (260)
Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor
Molecular Therapy: Nucleic Acids, 2014 Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors.
David Porciani +5 more
doaj +1 more source
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
Scientific Reports, 2016 Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells.
Valentina Cappello +7 more
doaj +1 more source
Nanophotonics, 2021 We demonstrate that electrically pumped random laser resonators, operating at terahertz (THz) frequencies, and comprising a quantum cascade laser heterostructure, can operate as sensitive photodetectors through the self-mixing effect.
Reichel Kimberly S. +7 more
doaj +1 more source
Application and Progress of Ion Chromatography in Food Analysis
Shipin gongye ke-ji, 2022 Ion chromatography (IC) is based on the differential promotion of the substance to be tested on the ion chromatography column, so as to separate different substances, and then determine the content of the substance to be tested through the detection ...
Chenying DAI +6 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Probing paper ageing by label-free fluorescence lifetime microscopy
Scientific ReportsPaper ageing is a complex and irreversible process that critically affects materials ranging from packaging to cultural heritage artefacts. While both invasive and non-invasive analytical techniques exist to assess the deterioration of paper, many ...
Francesca Di Turo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Communications BiologyIt is widely accepted that the pH of insulin granules is acidic, and that its active regulation during granule maturation plays a role in the process of insulin secretion by β-cells. Yet, a calibrated measurement of the absolute granule pH with organelle
Valentina De Lorenzi +7 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source