Results 31 to 40 of about 71,787 (267)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Nest and Unnest Operators in Nested Relations
Data Science Journal, 2008 By distinguishing nested attributes as Decomposable and Non-Decomposable, it is proved that for all nested relations, unnesting and then renesting on the same attribute yields the original relation subject only to the elimination of duplicate data. Therefore, the statement that was popular in nested relations research: "Unnesting and then nesting on ...
openaire +3 more sources
Discrete Applied Mathematics, 2002 Let all graphs \(G= (V,E)\) considered in the paper be simple and undirected ones. \(G\) is a generalization of the known interval graph if there is a set \(\{I_v\mid v\in V\}\) of intervals of the real line and a set \(\{\tau_v\mid v\in V\}\) of positive tolerances such that \(xy\in E\) iff \(|I_x\cap I_y|\geq \min\{\tau_x,\tau_y\}\). Such a graph \(G\
Ryan B. Hayward +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
The power of a critical heat engine
Nature Communications, 2016 The second law of thermodynamics says that the efficiency of a heat engine is limited by the Carnot efficiency. Here, the authors use finite-size-scaling theory to investigate whether this ultimate limit can be achieved at finite power using quantum Otto
Michele Campisi, Rosario Fazio
doaj +1 more source
Ultra-High-Frequency Love Surface Acoustic Wave Device for Real-Time Sensing Applications
IEEE Access, 2020 Love surface acoustic wave (L-SAW) devices are ideal for real-time sensing applications. High miniaturization and sensitivity are desirable in particular for point of care diagnostics or on-site measurements.
Gina Greco +2 more
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Experience with Treating Lentigo Maligna with Definitive Radiotherapy
Dermatology Research and Practice, 2018 Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a
Gerald B. Fogarty +3 more
doaj +1 more source