Results 1 to 10 of about 26,946 (162)

New facets of larger Nest motifs in proteins

Proteins: Structure, Function, and Bioinformatics, 2020
The Nest is a concave‐shaped structural motif in proteins formed by consecutive enantiomeric left‐handed (L) and right‐handed (R) helical conformation of the backbone.
D. Pal, S. Sahu, Raja Banerjee
semanticscholar   +1 more source

Real-time structural motif searching in proteins using an inverted index strategy

bioRxiv, 2020
Biochemical and biological functions of proteins are the product of both the overall fold of the polypeptide chain, and, typically, structural motifs made up of smaller numbers of amino acids constituting a catalytic center or a binding site.
S. Bittrich, S. Burley, Alexander S. Rose   +2 more
semanticscholar   +1 more source

Structural investigation of CDCA3‐Cdh1 protein–protein interactions using in vitro studies and molecular dynamics simulation

Protein Science, 2023
The anaphase‐promoting complex/cyclosome (APC/C) ubiquitin ligase and its cofactor, Cdh1, regulate the expression of several cell‐cycle proteins and their functions during mitosis.
Tabassum Khair Barbhuiya, M. Fisher, Eric D Boittier, E. Bolderson, K. O'Byrne, D. Richard, M. Adams, Neha S. Gandhi   +7 more
semanticscholar   +1 more source

Frontotemporal dementia‐linked P112H mutation of TDP‐43 induces protein structural change and impairs its RNA binding function

Protein Science, 2020
TDP‐43 forms the primary constituents of the cytoplasmic inclusions contributing to various neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia (FTD).
S. Agrawal, Monika Jain, Wei-Zen Yang, Hanna S. Yuan   +3 more
semanticscholar   +1 more source

Conditional Graphical Models for Protein Structural Motif Recognition

J. Comput. Biol., 2009
Determining protein structures is crucial to understanding the mechanisms of infection and designing drugs. However, the elucidation of protein folds by crystallographic experiments can be a bottleneck in the development process.
Yan Liu, J. Carbonell, Vanathi Gopalakrishnan, P. Weigele   +3 more
semanticscholar   +1 more source

The β-link motif in protein architecture.

Acta Crystallographica Section D: Structural Biology, 2021
The β-link is a composite protein motif consisting of a G1β β-bulge and a type II β-turn, and is generally found at the end of two adjacent strands of antiparallel β-sheet.
D. Leader, E. Milner-White
semanticscholar   +1 more source

Learning structural motif representations for efficient protein structure search

bioRxiv, 2017
Motivation Understanding the relationship between protein structure and function is a fundamental problem in protein science. Given a protein of unknown function, fast identification of similar protein structures from the Protein Data Bank (PDB) is a ...
Yang Liu, Qing Ye, Liwei Wang, Jian Peng
semanticscholar   +1 more source

Phylogenetic analysis and molecular structure of NS1 proteins of porcine parvovirus 5 isolates from Mexico

Archives of Virology
Porcine parvovirus 5 (PPV5) is an unclassified member of the family Parvoviridae with no reported pathogenicity, although it is associated with multisystemic, reproductive, and respiratory diseases.
Alejandro Vargas-Ruíz, D. M. Araiza-Hernández, F. González-Díaz, Ernesto Marín-Flamand, José Ivan Sánchez Betancourt, A. E. Sánchez-Mendoza, L. García-Camacho   +6 more
semanticscholar   +1 more source

Helix 8 is the essential structural motif of mechanosensitive GPCRs

Nature Communications, 2019
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia.
Serap Erdogmus, Ursula Storch, L. Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, A. Wirth, S. Offermanns, Carsten Hoffmann, T. Gudermann, M. Mederos y Schnitzler   +10 more
semanticscholar   +1 more source

A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin α‐dependent nuclear localization signals

Protein Science, 2023
Nucleocytoplasmic transport regulates the passage of proteins between the nucleus and cytoplasm. In the best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates ...
E. Cross, Nasim Akbari, Hanieh Ghassabian, M. Hoad, Silvia Pavan, Daryl Ariawan, C. M. Donnelly, Enrico Lavezzo, Gayle F. Petersen, J. Forwood, G. Alvisi   +10 more
semanticscholar   +1 more source