Results 31 to 40 of about 5,716 (123)

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

Long‐Read Whole‐Genome Sequencing Uncovers a Deletion Upstream to HOXD13 Causing Synpolydactyly

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Synpolydactyly (SPD) is a heterogeneous distal‐limb malformation syndrome, characterized by webbing and duplication of adjacent digits. SPD1, the most common type, is attributed to disease‐causing variants in HOXD13, a transcription factor in the HOXD cluster that is essential for limb development. Here, we present a challenging exome‐negative
Jonathan Rips, Rivka Birnbaum, Chaim Jalas, Ayala Frumkin, Shamir Zenvirt, Julia Rachanaev, Avraham Shaag, Tamar Harel, Orly Elpeleg, Hagar Mor‐Shaked   +9 more
wiley   +1 more source

The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization [PDF]

, 2018
Bacterial peptidoglycan glycosyltransferases (PGT) catalyse the essential polymerization of lipid II into linear glycan chains required for peptidoglycan biosynthesis.
Dowson, Christopher G., Khalid, Syma, Lloyd, Adrian J., Punekar, Avinash S., Roper, David I., Samsudin, Firdaus, Scott, David J.   +6 more
core   +3 more sources

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, EarlyView.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

Involvement of AmphiREL, a Rel-like gene identified in Brachiastoma belcheri, in LPS-induced response: Implication for evolution of Rel subfamily genes [PDF]

, 2012
Rel/NF-κB family genes are important transcriptional factors regulating vital activities of immunity response, but no Rel/NF-κB gene has been identified in amphioxus.
Chen, Liming, Hu, Jing, Jin, Ping, Li-Ling, Jesse, Ma, Fei, Qin, Sheng, Song, Xiaojun   +6 more
core   +1 more source

Microfluidic‐Assisted Evolution of a Robust NAD+‐Dependent Enzyme with Improved Isobutanol Tolerance at Elevated Temperatures

ChemSusChem, EarlyView.
Utilizing the power of the absorbance‐activated droplet sorter, a key enzyme for a cell‐free multienzymatic cascade for sustainable isobutanol biosynthesis is optimized for improved thermostability and isobutanol tolerance required for efficient cascade performance.
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber   +6 more
wiley   +1 more source

The Pseudorabies Virus DNA Polymerase Accessory Subunit UL42 Directs Nuclear Transport of the Holoenzyme [PDF]

, 2016
Pseudorabies virus (PRV) DNA replication occurs in the nuclei of infected cells and requires the viral DNA polymerase. The PRV DNA polymerase comprises a catalytic subunit, UL30, and an accessory subunit, UL42, that confers processivity to the enzyme ...
Chang-Ming Liu, Hong-Li Wu, Li Feng, Li-Ping Huang, Wen-Juan Du, Yan-Wu Wei, Yi-Ping Wang   +6 more
core   +2 more sources

Biomaterials‐Involved Construction of Extracellular Matrices for Tumor Blockade Therapy

Exploration, EarlyView.
Extracellular matrices (ECMs) play a crucial role in tumor growth and metastases by providing structural support and facilitating tumor cell proliferation. In this review, we explore the development of artificial ECMs engineered through biomineralization, fibrogenesis, and gelation. These bioinspired ECMs create a protective barrier around tumor cells,
Jinfeng Sun, Yang Liu, Jingshan Sun, Jianxun Ding, Xuesi Chen   +4 more
wiley   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source