Results 51 to 60 of about 26,946 (162)

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms

Epilepsia, EarlyView.
Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux, Laurence Chaton, Pierre Cleuziou, Anne‐Sophie Diependaële, Nathalie Bach, Nicolas Gruchy, Marion Gerard, Jean‐Pascal Meneboo, Céline Villenet, Martin Figeac, Emilie Ait‐Yahya, Caroline Thuillier, Elise Boudry, Adeline Trauffler, Sylvie Nguyen‐The‐Tich, Simon Boussion, Roseline Caumes, Jamal Ghoumid, Thomas Smol   +18 more
wiley   +1 more source

Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain

Protein Science
Hendra virus (HeV) is a biosafety level 4 human pathogen belonging to the Henipavirus genus within the Paramyxoviridae family. In HeV, the phosphoprotein‐encoding gene also drives the synthesis of the V and W proteins that are two major players in the ...
Frank Gondelaud, Julien Leval, Lisha Arora, Anuja Walimbe, C. Bignon, Denis Ptchelkine, Stefania Brocca, Samrat Mukhopadyay, Sonia Longhi   +8 more
semanticscholar   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Fibulin Family Members: New Players in Liver Fibrosis and Potential Biomarkers in Chronic Liver Diseases

Hepatology Research, EarlyView.
ABSTRACT Chronic liver diseases (CLD) arising from various etiologies including viral hepatitis, excessive alcohol intake, alcoholic associated liver disease (ALD) and metabolic dysfunction‐associated steatotic liver disease (MASLD), are associated with persistent hepatic injury ultimately resulting in fibrosis.
Fidaa Bouezzedine, Célia Thomas, Nathalie Théret   +2 more
wiley   +1 more source

Telotristat ethyl affects tumour‐fibroblast crosstalk in small intestinal neuroendocrine tumours

Journal of Neuroendocrinology, EarlyView.
Abstract Small intestinal neuroendocrine tumours (SI‐NETs) are associated with mesenteric fibrosis, which causes significant morbidity and mortality. Telotristat ethyl was developed to treat carcinoid syndrome in SI‐NET patients. Recent studies indicated telotristat ethyl could have anti‐tumour activity; however, the mechanism remains unclear.
Harry Hodgetts, Maria Castanho Martins, Luohai Chen, Andrew R. Hall, Tu Vinh Luong, Dalvinder Mandair, Martyn Caplin, Krista Rombouts   +7 more
wiley   +1 more source

Biocentric Work in the Anthropocene: How Actors Regenerate Degenerated Natural Commons

Journal of Management Studies, EarlyView.
Abstract As natural commons vital to selves, organizations, and institutions collapse under cumulative anthropogenic pressures, can human agency still reverse some of the damage already done? This article explores how emerging forms of social symbolic work regenerate degenerated natural commons.
Laura Albareda, Oana Branzei
wiley   +1 more source

Florigen Activation Complex Dynamics and SVP‐Mediated Repression Orchestrate Temperature‐Regulated Flowering in Saffron

Plant Biotechnology Journal, EarlyView.
ABSTRACT Saffron, a high‐value spice cultivated worldwide for its therapeutic and culinary uses, is a sterile triploid species, rendering conventional breeding approaches ineffective. This limitation underscores the need for molecular and biotechnological strategies for its genetic improvement. Flowering, a key determinant of saffron yield, is strongly
Diksha Kalia, Joel Jose‐Santhi, Firdous Rasool Sheikh, Rajesh Kumar Singh   +3 more
wiley   +1 more source

Molecular Evolution and Epidemiology of Benyviridae and the Agricultural Implications

Plant Pathology, EarlyView.
This study reveals Benyvirus diversity and evolution, highlighting their agricultural impact and the need for molecular surveillance to manage emerging plant viral diseases. ABSTRACT Viruses from the Benyviridae family are important aetiological agents of diseases in plants and are responsible for significant losses in agricultural production across ...
Simone de Oliveira Scherer, Emanuel Eliabe Alves, Dennis Maletich Junqueira, Ana Lucia Anversa Segatto   +3 more
wiley   +1 more source

Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing

Nature Structural & Molecular Biology
The NLRC4 inflammasome, vital for immune defense, responds to infections and inflammation. Here the authors reveal the role of Bacillus thailandensis type III secretion system needle protein in activating NLRC4 complex through structural insights.
Rosalie E Matico, Xiaodi Yu, Robyn Miller, Sandeep Somani, M. D. Ricketts, Nikit Kumar, R. Steele, Quintus Medley, Scott Berger, B. Faustin, Sujata Sharma   +10 more
semanticscholar   +1 more source