Results 51 to 60 of about 6,129 (164)

Genome analysis of two Pseudonocardia phylotypes associated with Acromyrmex leafcutter ants reveals their biosynthetic potential [PDF]

, 2016
The attine ants of South and Central America are ancient farmers, having evolved a symbiosis with a fungal food crop >50 million years ago. The most evolutionarily derived attines are the Atta and Acromyrmex leafcutter ants, which harvest fresh leaves to
Andersen, Andersen, Barke, Barke, Bentley, Brautaset, Cafaro, Caldera, Camacho, Chin, Clardy, Cotter, Currie, Currie, De Fine Licht, de Man, Doroghazi, Galinski, Gallucci, Gershenzon, Gross, Haeder, Hayashi, Hegemann, Kaltenpoth, Karakas Sen, Karki, Katz, Keatinge-Clay, Kieser, Kim, Kim, Larkin, Lazos, Lee, Li, Marsh, Nygaard, Oh, Piscotta, Poulsen, Poulsen, Richter, Robbel, Sapountzis, Scheuring, Schiøtt, Schoenian, Schultz, Seipke, Seipke, Seipke, Sen, Shigemori, Sit, Valdés-Stauber, Van Arnam, Walker, Walmsley, Weber, Wright   +60 more
core   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states [PDF]

, 2013
Flavivirus-infected cells secrete a structurally heterogeneous population of viruses because of an inefficient virion maturation process. Flaviviruses assemble as noninfectious, immature virions composed of trimers of envelope (E) and precursor membrane (
Austin, S. Kyle, Diamond, Michael S, Dowd, Kimberly A, Edeling, Melissa A, Fremont, Daved H, Lee, Phong D, Manhart, Carolyn J, Mukherjee, Swati, Pierson, Theodore C   +8 more
core   +2 more sources

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity [PDF]

, 2018
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2-Ub)(1). Ubiquitin ligases (E3s) of the 'really interesting new gene' (
A Borodovsky, A Hershko, A Plechanovová, AA Yunus, AF Alpi, Axel Knebel, B Grill, B Stieglitz, B Stieglitz, B Yang, BC Lechtenberg, Daan M. F. van Aalten, DM Wenzel, DS Hewings, E Babetto, G Langer, GN Murshudov, H Dou, HI Wan, J You, JE Brownell, JM Huibregtse, JN Pruneda, K Cadwell, Karim Rafie, Kay Hofmann, KC Pao, KK Dove, Kuan-Chuan Pao, L Conforti, M Scheffner, M Stanley, M Zhen, Mathew Stanley, MJ Niphakis, N Zheng, Nicola T. Wood, P Emsley, Peter D. Mabbitt, PY Wu, R Byrne, Ramasubramanian Sundaramoorthy, RJ Deshaies, S Milde, Satpal Virdee, SC Lovell, SK Olsen, X Wang, X Xiong, Y Shimizu, YO Ali   +50 more
core   +2 more sources

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology. [PDF]

, 2008
It seems well established that CpG oligonucleotides Th1 biased adjuvant activity can be improved when closely associated with a variety of antigens in, for example, microparticles.
Espuelas, S. (Socorro), Gamazo, C. (Carlos), Gomez, S. (Sara), Irache, J.M. (Juan Manuel), San-Roman, B. (Beatriz), Tsapis, N. (Nicolás)   +5 more
core  

Cas12Fold Accurately Predicts Cas12 Nuclease Structures to Enable Structure‐based Genome‐editing Engineering

Small Structures, EarlyView.
Cas12Fold, a deep‐learning framework tailored to Cas12 nucleases, uses evolutionary signals and iterative structure‐based alignment to resolve conformational complexity. This method outperforms general models in predicting key domains and states, accurately modeling enzymes such as Casλ.
Feng Xu, Zilong Zhao, Chang Liu, Meixia Yu, Ke Li, Yilin Jing, Peiyang Li, Beibei Xin, Jian Chen, Lizhu E, Jinsheng Lai, Zhijia Yang, Hainan Zhao   +12 more
wiley   +1 more source

Phosphorylation regulates human T-cell leukemia virus type 1 Rex function [PDF]

, 2009
Background: Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic complex deltaretrovirus, which is the causative agent of adult T-cell leukemia/lymphoma (ATL) and HTLV- 1-associated myelopathy/tropical spastic paraparesis.
Doueiri, Rami, Green, Patrick L., Kesic, Matthew, Semmes, O. John, Ward, Michael   +4 more
core   +2 more sources

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source