Results 61 to 70 of about 26,946 (162)

Breeding for delayed bolting decelerated the circadian clock in cultivated lettuce

New Phytologist, Volume 248, Issue 4, Page 1892-1902, November 2025.
Summary Circadian clocks pace biological events and influence developmental traits, but their role in leafy crop domestication has remained unexplored. We investigated whether selection for delayed bolting during lettuce domestication targeted clock components.
Cèlia Anton‐Sales, Esther S. van den Bergh, Alejandro Thérèse‐Navarro, Edouard Severing, Daniel Moñino‐López, Joseph DiPalma, Marcel Proveniers, C. Robertson McClung, Marieke Jeuken, Guusje Bonnema   +9 more
wiley   +1 more source

Accelerating NLRP3 drug discovery by leveraging a multipronged structural biophysics strategy

Structural Dynamics
NLRP3 is believed to be involved in many therapeutic indications, including Alzheimer's Disease, Parkinson's Disease, cardiovascular disease, atherosclerosis, cancer and metabolic disorders.
Jill Chrencik
semanticscholar   +1 more source

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

The structure of apo protein‐tyrosine phosphatase 1B C215S mutant: More than just an S → O change

Protein Science, 2001
G. Scapin, Sangita Patel, V. Patel, B. Kennedy, E. Asante-Appiah   +4 more
semanticscholar   +1 more source

Long‐Read Whole‐Genome Sequencing Uncovers a Deletion Upstream to HOXD13 Causing Synpolydactyly

American Journal of Medical Genetics Part A, Volume 197, Issue 10, October 2025.
ABSTRACT Synpolydactyly (SPD) is a heterogeneous distal‐limb malformation syndrome, characterized by webbing and duplication of adjacent digits. SPD1, the most common type, is attributed to disease‐causing variants in HOXD13, a transcription factor in the HOXD cluster that is essential for limb development. Here, we present a challenging exome‐negative
Jonathan Rips, Rivka Birnbaum, Chaim Jalas, Ayala Frumkin, Shamir Zenvirt, Julia Rachanaev, Avraham Shaag, Tamar Harel, Orly Elpeleg, Hagar Mor‐Shaked   +9 more
wiley   +1 more source

GRPa‐PRS: A risk stratification method to identify genetically‐regulated pathways in polygenic diseases

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Polygenic risk score (PRS) assesses genetic risk for diseases, yet some high‐risk individuals avoid illness while low‐risk individuals develop it. We hypothesize that unknown counterfactors may reverse PRS predictions, offering insights into disease mechanisms and interventions.
Xiaoyang Li, Brisa S. Fernandes, Andi Liu, Jingchun Chen, Xiangning Chen, Zhongming Zhao, Yulin Dai   +6 more
wiley   +1 more source

On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality

Protein Science
The humanization of camelid‐derived variable domain heavy chain antibodies (VHHs) poses challenges including immunogenicity, stability, and potential reduction of affinity.
M. Fernández-Quintero, Enrico Guarnera, Djordje Musil, Lukas Pekar, Carolin Sellmann, Filipe Freire, Raquel L. Sousa, Sandra P Santos, Micael C Freitas, Tiago M. Bandeiras, Margarida M S Silva, Johannes R. Loeffler, Andrew B. Ward, Julia Harwardt, Stefan Zielonka, Andreas Evers   +15 more
semanticscholar   +1 more source

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source

A Chromosome Inversion Creates a Supergene for Sex and Colour in Lake Malawi Cichlids

Molecular Ecology, Volume 34, Issue 20, October 2025.
ABSTRACT Cichlid fishes have the highest rates of evolutionary turnover of sex chromosomes among vertebrates. Many large structural polymorphisms in the radiation of cichlids in Lake Malawi are associated with sex chromosomes and may also carry adaptive variation.
Kristen A. Behrens, Soumya Jailwala, Frances E. Clark, Anne C. Meyer, Nikesh M. Kumar, Adrianus F. Konings, Reade B. Roberts, Matthew A. Conte, Jeffrey T. Streelman, Patrick T. McGrath, Thomas D. Kocher   +10 more
wiley   +1 more source

PagMIR166c targets PagECH2 to regulate cambial differentiation into secondary xylem, cell expansion, and lignin deposition via different auxin signaling pathways in poplar stems

New Phytologist, Volume 248, Issue 1, Page 321-338, October 2025.
Summary Secondary xylem, a key trait of trees, is the main source of tree biomass. MicroRNAs (miRNAs) play important regulatory roles in the secondary xylem formation; however, the underlying regulatory mechanisms are far from being completely elucidated.
Pan Zhao, Xinyi Zhou, Qiulin Yu, Yuting Su, Ran Liu, Shuya Zheng, Huihong Guo   +6 more
wiley   +1 more source