Results 91 to 100 of about 933,433 (278)

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Nested array with time-delayers for target range and angle estimation [PDF]

, 2015
Since a nested phased array cannot directly estimate the range of targets due to range ambiguity, this paper proposes a nested array with diverse time-delayers for target range and angle estimation.
Wen-Qin Wang, null Cong Ling, Wang, WQ, Ling, C   +3 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Non-Circular Signal DOA Estimation with Nested Array via Off-Grid Sparse Bayesian Learning. [PDF]

Sensors (Basel), 2023
Dong X, Zhao J, Sun M, Zhang X.
europepmc   +1 more source

Shifted super transformed nested array for DOA estimation of non-circular signals with increased uDOFs and reduced mutual coupling [PDF]

In this work, a scheme for array structure design is proposed to maximize uniform degrees of freedom (uDOFs) and reduce mutual coupling. It starts by exchanging the positions of two subarrays within the nested array, followed by mitigating mutual ...
Zhu, M, Wang, G, Li, J, Liu, W, Wang, Q, Chen, H   +5 more
core   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Noncircular Distributed Source DOA Estimation with Nested Arrays via Reduced-Dimension MUSIC

Sensors
This paper focuses on the direction-of-arrival (DOA) estimation for noncircular coherently distributed (CD) sources with nested arrays. Usually, for point sources, sparse arrays have the potential to improve the estimation performance of algorithms by ...
Kaiyuan Chen, Weiyang Chen, Jiaqi Li
doaj   +1 more source

Model Specification Tests Against Non-Nested Alternatives [PDF]

Non-nested hypothesis tests provide a way to test the specification of an econometric model against the evidence provided by one or more non-nested alternatives.
James G. MacKinnon
core  

Integrating Kinetics into Synthetic Studies via Adaptable Concentration‐Dependent Yield Analysis

Advanced Science, EarlyView.
A method to derive kinetic parameters from synthetic studies was developed and named concentration‐dependent yield analysis (CYAN). Using numerical Euler integration for kinetic regression, CYAN was proven adaptable to chemical and operational considerations and revealed unexpected template effects of a transition metal that mediated competitive ...
Xinyi Xiao, Koki Ikemoto, Toshiya M. Fukunaga, Hideaki Nishina, Hiroyuki Isobe   +4 more
wiley   +1 more source

New Directions In Sparse Sampling and Estimation For Underdetermined Systems [PDF]

, 2013
A central objective in signal processing is to infer meaningful information from a set of measurements or data. While most signal models have an overdetermined structure (the number of unknowns less than the number of equations), traditionally very few ...
Piya Pal, Pal, Piya
core   +1 more source