Results 91 to 100 of about 457,797 (282)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

NESTED CELLULAR ARRAYS TO SOLVE LARGE SETS OF LINEAR EQUATIONS

open access: yes, 1984
Nested cellular arrays (NCAs) to solve large sets of linear equations are considered. It is shown that the number of scalar cells (nsc), which characterizes the aggregate chip area for the array, is the same as for regular cellular arrays (RCAs).
Bickart, Theodore A.   +1 more
core  

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

open access: yesAdvanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne   +15 more
wiley   +1 more source

Transmit and Receive Array Structure Design of Two-Dimensional hybrid Phased-MIMO Radar based on Nested Array

open access: yesMATEC Web of Conferences, 2018
In order to reduce the loss of Degree of Freedom (DOF) brought by the transmit subarray splitting of two-dimensional hybrid phased-MIMO radar, this paper presents a design method of transmitting and receiving array based on nested array structure ...
Cheng Tianhao   +3 more
doaj   +1 more source

Integrating Kinetics into Synthetic Studies via Adaptable Concentration‐Dependent Yield Analysis

open access: yesAdvanced Science, EarlyView.
A method to derive kinetic parameters from synthetic studies was developed and named concentration‐dependent yield analysis (CYAN). Using numerical Euler integration for kinetic regression, CYAN was proven adaptable to chemical and operational considerations and revealed unexpected template effects of a transition metal that mediated competitive ...
Xinyi Xiao   +4 more
wiley   +1 more source

Arthropod‐Inspired Miniature Modular Vibration Direct‐Drive Robot With Untethered Locomotion

open access: yesAdvanced Science, EarlyView.
This work presents an arthropod‐inspired untethered miniature modular vibration direct‐drive robot. By utilizing standardized driving units and nested locking interfaces, on‐demand reconfiguration into quadruped, hexapod, octopod, and circular morphologies is achieved.
Shijing Zhang   +4 more
wiley   +1 more source

Sparse Extension Array Geometry for DOA Estimation With Nested MIMO Radar

open access: yesIEEE Access, 2017
The two-level nested array geometry, which systematically nests two uniform linear subarrays, is proved to offer O(N2) degrees of freedom (DOFs) with only N sensors.
Wang Zheng, Xiaofei Zhang, Junpeng Shi
doaj   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

open access: yesAdvanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu   +15 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang   +11 more
wiley   +1 more source

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