Results 111 to 120 of about 1,883,994 (277)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
, 2012 Net@work: a net for employment. Measures and interventions for disadvantaged groups. Presentations by the Member States, Interventi all’evento di scambio della Rete Net@work “Measures and interventions for disadvantaged groups”, Vilnius, 6-7 giugno 2012.
Net@work: a net for employment
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Indian Journal of Endocrinology and MetabolismIntroduction: Functioning neuroendocrine tumors (NETs) that do not respond to standard therapies are commonly considered for Peptide Receptor Radionuclide Therapy (PRRT).
David Mathew +7 more
doaj +1 more source
Oktatóprogram fejlesztése .net környezetben
, 2019 Szakdolgozatunk témája az oktatóprogramok fejlesztése és vizsgálata. Ennek keretein belül egy angol nyelvoktató programot hoztunk létre .NET környezetben. Munkánk két különálló szakdolgozatként találhatók meg.
Simon, László, Soós, Árpád
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A rainha virtual The virtual queen
Estudos de Sociologia, 2007 Em um breve período, o artigo pode ser assim resumido: o debate sobre a transversalidade na educação, necessariamente, deve incluir a idéia de rede e o debate tecnológico sobre a Internet: como meio, instrumento e ferramenta que melhor expressa a própria
Vinício Carrilho Martinez
doaj