Results 121 to 130 of about 791,781 (169)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays.

Lab Chip
Kadivar N, Li G, Zheng J, Dao M, Karniadakis GE, Xu M.   +5 more
europepmc   +1 more source

Rethinking energy transition strategies for the European Union amid rising energy prices. [PDF]

Proc Natl Acad Sci U S A
Meng W, Nieto J, Guan D, Meng J, Sander R, Pöschl U, Hubacek K, Su H, Tao S, Cheng Y.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Impact of data augmentation size on deep learning-based third lumbar vertebra computed tomography skeletal muscle segmentation performance. [PDF]

Quant Imaging Med Surg
Zhao X, Du Y, Zhu X, Liu Y, Xiao Y, Tian H.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

High mortality at safety-net hospitals for patients with cirrhosis. [PDF]

Hepatol Commun
Shah S, Yilma M, Omer S, Shui A, Kim NJ, Zhou K, Tana M, Mehta N.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis. [PDF]

Endocr Pathol
Vanoli A, Xue Y, Kasajima A, Ruffoni R, Tarcan ZÇ, Tezcan N, Liu X, Navale P, Mohamed A, Gullo I, Silva R, Vocino Trucco G, Volante M, Disanto MG, Taverna C, Kuzucular E, Luchini C, Roa JC, Esposito I, La Rosa S, Pehlivanoglu B, Reid M, Klöppel G, Basturk O, Adsay V.   +24 more
europepmc   +1 more source