Results 91 to 100 of about 1,928,288 (290)

Measurements of the fluctuations of identified particles in ALICE at the LHC

, 2019
The event-by-event fluctuations of identified particles in ultrarelativistic nucleus-nucleus collisions give information about the state of matter created in these collisions as well as the phase diagram of nuclear matter. In this proceedings, we present
Ohlson, Alice
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Nuclear Stopping in Au+Au Collisions at sqrt(sNN) = 200 GeV

, 2004
Transverse momentum spectra and rapidity densities, dN/dy, of protons, anti-protons, and net--protons (p-pbar) from central (0-5%) Au+Au collisions at sqrt(sNN) = 200 GeV were measured with the BRAHMS experiment within the rapidity range 0 < y < 3.
A. Holm, A. Jipa, A. K. Holme, A. Makeev, B. Budick, B. H. Samset, B. S. Nielsen, C. Besliu, C. Chasman, C. E. Jørgensen, C. H. Christensen, C. Ristea, D. Beavis, D. Ouerdane, D. Röhrich, D. Sandberg, E. Enger, E. J. Kim, F. Jundt, F. Rami, F. Videbæk, G. Løvhøiden, H. Bøggild, H. Ito, I. G. Bearden, I. S. Zgura, J. Cibor, J. H. Lee, J. I. Jørdre, J. J. Gaardhøje, J. Natowitz, J. Norris, K. Hagel, K. Olchanski, M. Germinario, M. Mikelsen, M. Murray, O. Hansen, P. Christiansen, P. Staszel, R. A. Scheetz, R. Debbe, R. Karabowicz, R. Płaneta, R. Wada, S. J. Sanders, T. Kozik, T. M. Larsen, T. S. Tveter, Y. K. Lee, Z. Majka, Z. Yin   +51 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Optimizing The Net Energy of Acetone Production using The Isopropyl Alcohol Dehydrogenation Process

Journal of Chemical Engineering Research Progress
In order to reduce the dependence on fossil fuels, acetone has emerged as an important platform chemical for various industrial applications. Acetone can be efficiently produced through the dehydrogenation of isopropanol, using metal-based catalysts with
Ahmad Nur Ihsan, Angga Satria Wibawa, Dafiq Ruliyono, Kevin Maulana Ibrahim, Muhammad Alif Kindi   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exigências nutricionais de proteína, energia e macrominerais de bovinos Nelore de três classes sexuais Nutrient requirements of protein, energy and macrominerals of Nellore cattle of three genders

Revista Brasileira de Zootecnia, 2009
Objetivou-se determinar as exigências de energia metabolizável para mantença, as exigências líquidas de proteína, energia e macrominerais para ganho de peso e a eficiência de transformação de exigências líquidas de proteína para ganho em exigências de ...
Marcos Inácio Marcondes, Sebastião de Campos Valadares Filho, Pedro Veiga Rodrigues Paulino, Rilene Ferreira Diniz Valadares, Mário Fonseca Paulino, Fernando Barros Nascimento, Mozart Alves Fonseca   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source