Results 91 to 100 of about 1,934,125 (288)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPLICATIONS OF A CARBON BASED ENERGY TAX FOR U.S. AGRICULTURE [PDF]

Policies to mitigate greenhouse gas emissions are likely to increase the prices for fossil fuel based energy. Higher energy prices would raise farmers' expenditure on machinery fuels, irrigation water, farm chemicals, and grain drying.
Bruce A. McCarl, Uwe A. Schneider
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Optimizing The Net Energy of Acetone Production using The Isopropyl Alcohol Dehydrogenation Process

Journal of Chemical Engineering Research Progress
In order to reduce the dependence on fossil fuels, acetone has emerged as an important platform chemical for various industrial applications. Acetone can be efficiently produced through the dehydrogenation of isopropanol, using metal-based catalysts with
Ahmad Nur Ihsan, Angga Satria Wibawa, Dafiq Ruliyono, Kevin Maulana Ibrahim, Muhammad Alif Kindi   +4 more
doaj   +1 more source

Exigências nutricionais de proteína, energia e macrominerais de bovinos Nelore de três classes sexuais Nutrient requirements of protein, energy and macrominerals of Nellore cattle of three genders

Revista Brasileira de Zootecnia, 2009
Objetivou-se determinar as exigências de energia metabolizável para mantença, as exigências líquidas de proteína, energia e macrominerais para ganho de peso e a eficiência de transformação de exigências líquidas de proteína para ganho em exigências de ...
Marcos Inácio Marcondes, Sebastião de Campos Valadares Filho, Pedro Veiga Rodrigues Paulino, Rilene Ferreira Diniz Valadares, Mário Fonseca Paulino, Fernando Barros Nascimento, Mozart Alves Fonseca   +6 more
doaj   +1 more source

Parameters of the Magnetic Flux inside Coronal Holes

, 2009
Parameters of magnetic flux distribution inside low-latitude coronal holes (CHs) were analyzed. A statistical study of 44 CHs based on Solar and Heliospheric Observatory (SOHO)/MDI full disk magnetograms and SOHO/EIT 284\AA images showed that the density
A.C. Balke, B. Vrs̆nak, C.J. Schrijver, C.J. Schrijver, C.J. Schrijver, C.J. Schrijver, C.J. Schrijver, C.J. Schrijver, C.N. Arge, D.A. Lamb, D.W. Longcope, F. Moreno-Insertis, H.J. Hagenaar, Hiroko Watanabe, J. Harvey, J.-P. Delaboudiniere, J.K. Lawrence, J.W. Harvey, K. Ichimoto, K. Janssen, K.L. Harvey, L.A. Fisk, L.A. Fisk, L.A. Fisk, L.A. Fisk, M. Schroeder, N. Meunier, N.R. Sheeley Jr., P.H. Scherrer, S. Kamio, S. Robbins, S. Tsuneta, T. Wiegelmann, T. Wiegelmann, T.D. Tarbell, T.E. Berger, T.E. Berger, U. Frisch, V. Bumba, V. Obridko, V.I. Abramenko, V.I. Abramenko, V.I. Abramenko, V.I. Abramenko, V.I. Abramenko, V.I. Abramenko, V.N. Obridko, Valentyna Abramenko, Vasyl Yurchyshyn, Y.M. Wang, Y.M. Wang, Y.M. Wang   +51 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparing Apples to Apples: Why the Net Energy Analysis Community Needs to Adopt the Life-Cycle Analysis Framework

Energies, 2016
How do we know which energy technologies or resources are worth pursuing and which aren’t? One way to answer that question is to compare the energy return of a certain technology—i.e., how much energy is remaining after accounting for the amount of ...
David J. Murphy, Michael Carbajales-Dale, Devin Moeller   +2 more
doaj   +1 more source