Results 81 to 90 of about 2,106,515 (290)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Exploring HIV self-testing and implementation determinants among migrants: perspectives from West, East, Central, and Southern African migrants and key informants in the Netherlands

open access: yesHIV Research & Clinical Practice
Background HIV self-testing (HIVST) has the potential to increase testing uptake among populations underserved by facility/clinic-based services, including African migrants in Europe.
Oladipupo Shobowale   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Kingdom of the Netherlands—Netherlands

open access: yesIMF Staff Country Reports, 2014
This 2014 Article IV Consultation highlights that the Dutch economy continues to improve, supported by exports, rising housing prices, and improving sentiment. Exports are rising on expanding global trade, but consumption remains sluggish as indebted households continue to save. The external current account surplus now exceeds 10 percent of GDP, led by
openaire   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Netherlands 1962

open access: yes, 1962
Bijgewerkt ... [1962]Depths shown by bathymetric isolines, bathymetric tints and soundings.; Map in 2 segments.; Date derieved from purple stamp.; Includes notes, conversion table and 1 inset map: [Dordrecht]; Annotations in pencil.; Selected lights ...
Netherlands. Hydrografisch Bureau;
core  

Special Education Systems in Five Countries: Indonesia, Norway, Malaysia, Netherlands, Thailand

open access: yesJournal of ICSAR, 2020
This article discusses a comparison of special education in five countries. Two countries are on the continent of Europe, and three other countries are on Asia's continent. This article describes the forms of special education that exist in each country.
Dewi Kurniati, Herry Widyastono
doaj  

Woonschool

open access: yesПроект Байкал, 2018
The Dutch embraced in the 1920s the idea that they could improve society by forcing antisocial families in so-called housing schools. Slums were cleared under the pre-text of urban renewal, and vulnerable families were put under supervision in special ...
Frank van der Hoeven
doaj   +1 more source

Formation of milk prices in Ukraine in the context of world trends

open access: yesAgricultural and Resource Economics, 2020
Purpose. The purpose of this article is to assess trends in milk prices in Ukraine in comparison with other countries, identify patterns in their change and to test our own methodological approach to estimating the level of variation in time series ...
Natalia Shyian, Valerii Kolosha
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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