Results 21 to 30 of about 960 (201)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
The role of emotional intelligence in enhancing intercultural sensitivity [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Emotions have been noted for their crucial role in survival behaviour relating to resistance to cross-cultural ambiguity.
Saberi, Maria Akbar
core
Uso de inteligencia artificial en ortodoncia para el apoyo en la toma de decisión de extracción y seleccion entre los primeros y segundos premolares mediante el uso de variables cefalometricas extraidas de una muestra de población del Valle del Cauca [PDF]
La extracción dental en ortodoncia constituye una decisión clínica irreversible con importantes implicaciones estéticas y funcionales, que exige un delicado equilibrio entre la generación de espacio para resolver discrepancias dentoalveolares y la ...
Ferro Sánchez, Carlos Andrés
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
, 2000 본 연구의 목적은 중학생들의 쓰기 능력을 향상시키기 위해서 과정 중심의 쓰기 전략을 실제 수업에 활용하여 적용하는 데 있다. 그 이전에 지금까지 진행된 과정 중심의 쓰기 전략에 대한 구체적인 연구들을 이론적으로 검토하고, 그것을 토대로 하여 과정 중심의 쓰기 전략을 중학교 학생들의 쓰기 수업에 적용하여 보았다. 그 결과 학생들의 쓰기 태도면에서 긍정적인 변화를 가져왔으며 쓰기 능력에 있어서도 의미 있는 향상을 보였다. 쓰기는 국어 교과에서 최종적인
박은경
core
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source