Results 41 to 50 of about 217,099 (241)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Psychometric Evaluation of the Insomnia Severity Index in Chronic Disease Patients Using Three Complementary Approaches

Brain and Behavior
Background Insomnia is highly prevalent among individuals with chronic diseases and often exacerbates disease progression while adversely impacting mental health and quality of life.
Firoj Al‐Mamun, Mohammed A. Mamun, Mohammad Arif, Pronab Das, Moneerah Mohammad ALmerab, David Gozal   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Reliability Indicators of Urban Electric Network Schemes for Supply of Second and Third Category Consumers

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2012
The paper considers two schemes of the urban distributive electric network for supply of the second and third category consumers for whom indicators of reliability have been determined.As for a network scheme of the 2nd category it has been determined ...
M. A. Korotkevich, A. L. Starzhinsky
doaj  

Research for the Influence of Distribution Network Line Reclosing Current on Line Protection

MATEC Web of Conferences, 2016
According to the distribution network line structure and reclosing control strategy, the system simulation model of distribution network lines has established based on the real-time digital simulation RTDS.
Yu Kansheng, Wu Ying, Fan Ruixiang, Pan Benren, Cao Bei   +4 more
doaj   +1 more source

Disjoint Spanning Tree Based Reliability Evaluation of Wireless Sensor Network

Sensors, 2020
Wireless sensor networks (WSNs) are becoming very common in numerous manufacturing industries; especially where it is difficult to connect a sensor to a sink. This is an evolving issue for researchers attempting to contribute to the proliferation of WSNs.
Sonam Lata, Shabana Mehfuz, Shabana Urooj, Asmaa Ali, Nidal Nasser   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Modeling of Microgrids to Reduce Market-Oriented Reliability Costs, Considering the Shape Factor of the Load Curve

International Transactions on Electrical Energy Systems
The increasing integration of renewable energy resources necessitates efficient energy management frameworks, among which we can refer to microgrids. Microgrids have many advantages, one of which is the reduction of reliability costs.
Haniyeh Katiraee, Hassan Jalili
doaj   +1 more source