Results 61 to 70 of about 217,099 (241)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An examination of validity and reliability of the Parental Stress Scale in a population based sample of Norwegian parents.

PLoS ONE, 2020
The parental stress scale (PSS) is a widely used instrument that assesses stress related to child rearing. Even though several studies have investigated the construct validity and reliability of the PSS, no consensus has been reached regarding which and ...
Ane Nærde, Silje Sommer Hukkelberg
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Network modelling and computation of quickest path for service-level agreements using bi-objective optimization

International Journal of Distributed Sensor Networks, 2019
This article addresses the problem related to the reliability of path after transmitting the given amount of data with the service-level agreement cooperation in the computer communication network.
Ashutosh Sharma, Rajiv Kumar, Manar Wasif Abu Talib, Saurabh Srivastava, Razi Iqbal   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

DS+: Reliable Distributed Snapshot Algorithm for Wireless Sensor Networks

Journal of Computer Networks and Communications, 2013
Acquiring the snapshot of a distributed system helps gathering system related global state. In wireless sensor networks (WSNs), global state shows if a node is terminated or deadlock occurs along with many other situations which prevents a WSN from fully
Gamze Uslu, Kemal Cagri Serdaroglu, Sebnem Baydere   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Psychometric properties of the pain anxiety symptom scale among postoperative patients in Amol, Iran

Frontiers in Psychiatry
IntroductionSo far, the psychometric properties of the Persian version of the Pain Anxiety Symptom Scale have not been assessed in Iran. Therefore, this study was conducted to determine the validity and reliability of the Persian version of the Pain ...
Hamid Sharif-Nia, Hamid Sharif-Nia, Erika Sivarajan Froelicher, Erika Sivarajan Froelicher, João Marôco, Esmaeil Hoseinzadeh, Sima Hejazi, Sima Hejazi, Reza Fatehi, Poorya Nowrozi, Bita Mohammadi   +10 more
doaj   +1 more source