Results 61 to 70 of about 663,074 (305)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Soil data from the Barbastro-Balaguer gypsum belt, NE SpainMendeley Data

Data in Brief
The dataset [1] hosts pedological info and images of the lands —locally known as chesas— of the outcropping gypsiferous core of the Barbastro-Balaguer anticline (Fig. 1).
Juan Herrero, María Tierra, Carmen Castañeda   +2 more
doaj   +1 more source

Areas of the European Ecological Network Natura 2000 in Roztocze

Barometr Regionalny, 2015
The Natura 2000 network includes Special Areas of Conservation SACs (habitat refuges coded PLH ) and Special Protection Areas SPA (bird refuges coded PLB).
Wioletta Kałamucka, Krzysztof Kałamucki, Małgorzata Stanicka   +2 more
doaj   +1 more source

“Mind the gap!” – How well does Natura 2000 cover species of European interest?

Nature Conservation, 2012
Setting aside protected areas is widely recognized as one of the most effective measures to prevent species from extinction. Accordingly, there has been a tremendous effort by governments worldwide to establish protected areas, resulting in over 100,000 ...
Bernd Gruber, Douglas Evans, Klaus Henle, Bianca Bauch, Dirk Schmeller, Frank Dziock, Pierre-Yves Henry, Szabolcs Lengyel, Chris Margules, Carsten Dormann   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Catholic Women's Network, September / October, 2000

, 2000
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source

Assessment and governance of Ecosystem Services for improving management effectiveness of Natura 2000 sites

Bio-based and Applied Economics, 2014
The Natura 2000 network is the cornerstone of the EU Biodiversity Strategy aimed at halting the loss of biodiversity and ecosystem services. Yet in many EU Member States the level of development and execution of management plans and conservation measures
Davide Marino, Pierluca Gaglioppa, Uta Schirpke, Rossella Guadagno, Angelo Marucci, Margherita Palmieri, Davide Pellegrino, Natalia Gusmerotti   +7 more
doaj   +1 more source

The ASCI Network for SC 2000: Gigabyte Per Second Networking [PDF]

, 2001
This document highlights the Discom's Distance computing and communication team activities at the 2000 Supercomputing conference in Dallas Texas. This conference is sponsored by the IEEE and ACM. Sandia's participation in the conference has now spanned a decade, for the last five years Sandia National Laboratories, Los Alamos National Lab and Lawrence ...
Pratt, Thomas J., Naegle, John H., Martinez, Luis G., Jr., Hu, Tan Chang, Miller, Marc M., Barnaby, Marty L., Adams, Roger L., Klaus, Edward J.   +7 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source