Results 71 to 80 of about 663,074 (305)

Species, habitats, society: an evaluation of research supporting EU's Natura 2000 network.

PLoS ONE, 2014
The Natura 2000 network is regarded as one of the conservation success stories in the global effort to protect biodiversity. However, significant challenges remain in Natura 2000 implementation, owing to its rapid expansion, and lack of a coherent vision
Viorel D Popescu, Laurentiu Rozylowicz, Iulian M Niculae, Adina L Cucu, Tibor Hartel   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

International Network Non-energy Use and CO2 Emissions (NEU-CO2). Final Report of the First Phase of the Network (January 1999-June 2000)

, 2022
This report concludes the first phase of the NEU-CO2 network, covering the period from January 1999 to June 2000. Within this period, two workshops were held, one in Paris in September 1999 and the other in Brussels in April 2000.
Kilde, N., Gielen, D., Simmons, T., Patel, M.   +3 more
core  

Crop wild relatives in Natura 2000 Network [PDF]

, 2021
This document presents the results of analyses to ascertain the potential of the Natura 2000 network to conserve crop wild relatives (CWR). We obtained distribution data of European priority CWR from large international biodiversity databases and ...
Kell, Shelagh, Gaisberger, Hannes, Iriondo, Jose Maria, Maxted, Nigel, Rubio Teso, Maria Luisa, Lara-Romero, Carlos, Álvarez Muñiz, Clara, Magos Brehm, Joana   +7 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

GPS Tracking Reveals the White-Tailed Eagle Haliaeetus albicilla as an Ambassador for the Natura 2000 Network

Diversity
The Natura 2000 network of protected areas is the backbone of species conservation in the European Union. We investigated whether Austrian-hatched white-tailed eagles (Haliaeetus albicilla) make particular use of this multinational network during their ...
Remo Probst, Matthias Schmidt, Michael McGrady, Christian Pichler   +3 more
doaj   +1 more source

Network lifetime compare for 2000 sensors.

, 2020
Network lifetime compare for 2000 sensors.
Xiucai Ye (8259642), Jing Zhang (23775), Pei-Wei Tsai (5220653), Shunmiao Zhang (8259645), Xingsi Xue (6598004)   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Red Natura 2000: margen de apreciación estatal, evaluación de la importancia comunitaria de los lugares y situación actual de la red en Gipuzkoa

Revista Vasca de Administración Pública, 2013
Natura 2000 is the European ecologic network designed by the Habitats Directive and it pursues the objective of conservation of natural habitats and species. In its creation, several stages are to be distinguished.
Juan José Pérez Pérez
doaj   +1 more source