Results 131 to 140 of about 2,889,825 (317)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Understanding relational inclusivity through a social network analysis toolkit

Some of the latest research on Social Network Analysis (SNA) and education shows that increased social network connectivity among students has benefits for their academic, social, and emotional development.
Mejeh, Mathias, Michail, Georgios, Mamas, Christoforos   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multi-Level Intertemporal Attention-Guided Network for Change Detection in Remote Sensing Images

Remote Sensing
Change detection (CD) is detecting and evaluating surface changes by comparing Remote Sensing Images (RSIs) at different times, which is of great significance for environmental protection and urban planning.
Shuo Liu, Qinyu Zhang, Yuhang Zhang, Xiaochen Niu, Wuxia Zhang, Fei Xie   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circulating Factors as Potential Biomarkers of Cardiovascular Damage Progression Associated with Type 2 Diabetes

Proteomes
Background: Diabetes, particularly type 2 diabetes (T2D), is linked with an increased risk of developing coronary heart disease (CHD). The present study aimed to evaluate potential circulating biomarkers of CHD by adopting a targeted proteomic approach ...
Giovanni Sartore, Francesco Piarulli, Eugenio Ragazzi, Alice Mallia, Stefania Ghilardi, Massimo Carollo, Annunziata Lapolla, Cristina Banfi   +7 more
doaj   +1 more source

Investigating Brain-Behavior Architecture Using Graph-Based Network Analysis: Preliminary Insights from Resting-State fMRI

openUnderstanding how the brain supports various cognitive and behavioral functions requires moving beyond isolated domains to a multimodal network-level approach.
OZER, ZEYNEP GOKCEN
core  

Global Buildings Performance Network (GBPN)

, 2015
The GBPN’s goal is to contribute to the building sector achieving its full energy savings and CO2mitigation potential of more than 2.1 Gt by 2030. The GBPN was founded in 2010 with the mandate to advance knowledge and expertise globally on building ...
Global Buildings Performance Network
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Spatial-Temporal Semantic Feature Interaction Network for Semantic Change Detection in Remote Sensing Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Semantic Change Detection (SCD) in Remote Sensing Images (RSI) aims to identify changes in the type of Land Cover/Land Use (LCLU). The “from-to” information of the acquired image has more profound practical significance than Binary Change ...
Yuhang Zhang, Wuxia Zhang, Songtao Ding, Siyuan Wu, Xiaoqiang Lu   +4 more
doaj   +1 more source