Results 101 to 110 of about 1,281,547 (267)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Network Control System Upgrade and Reconnection Modificationof CCQG Light Railway Vehicle

机车电传动, 2014
Control principle, merits and drawbacks of CCQG light railway vehicle existing network control system were expounded, andbased above, upgrade and reconnection modification scheme was presented.
ZHOU Xiao, LIU Yan-hui, HUANG Wei, MA Yu-fan   +3 more
doaj  

Water Network Loss Control System

Engineering Proceedings
This study addresses the issue of water losses in drinking water distribution networks, a problem exacerbated by climate change, drought, and aging infrastructure.
Silvie Drabinová, Petra Malíková, Petr Černoch   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimization Control of the Gateway Redundancy for HXD1 Electric Locomotive and Its Realization

Kongzhi Yu Xinxi Jishu, 2019
To solve the problem of pantograph automatically dropping caused by gateway redundancy switching, it proposed a control strategy based on new gateway redundancy switching. The implementation of the strategy was also analyzed.
WANG Yu, YUAN Lu, LI Peng, JIANG Weibo
doaj  

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for Candidozyma auris

Antimicrobial Stewardship & Healthcare Epidemiology
Following the implementation of in-house Candidozyma auris (C. auris) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C.
Rossana Rosa, Gemma Rosello, Kelley Manzanillo, Octavio V. Martinez, Lilian M. Abbo   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

When semantic plausibility becomes a liability: LLM-based phishing detection from an adversarial asymmetry perspective

Cyber Security and Applications
With the rise of generative AI, a new generation of intelligent phishing has emerged, where attackers leverage Large Language Models (LLMs) to craft websites with high semantic plausibility, posing critical challenges to traditional defenses.
Yanjun Li, Ziyu Wang, Yitong Ren, Xu Yang, Yuan Liu, Zhihong Tian   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Optimal Control of Whole Network Control System Using Improved Genetic Algorithm and Information Integrity Scale.

Comput Intell Neurosci, 2022
Ma X.
europepmc   +1 more source