Results 151 to 160 of about 876,573 (316)
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Non-stationary network flow is considered. Definitions of non-stationary network flow, amount of flow in T time, average amount of flow are given. Limitation on the average amount of flow is found.
Y.M. ERUSALIMSKY, N.N. VODOLAZOV
doaj
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Non-stationary network flow is considered. Definitions of non-stationary network flow, amount of flow in T time, average amount of flow are given. Limitation on the average amount of flow is found.
Y.M. ERUSALIMSKY, N.N. VODOLAZOV
doaj
Endogenous labour flow networks
Abstract In the last decade, the study of labour dynamics has led to the introduction of labour flow networks (LFNs) as a way to conceptualise job-to-job transitions, and to the development of mathematical models to explore the dynamics of these networked flows.
Kathyrn R. Fair, Omar A. Guerrero
openaire +5 more sources
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Network Communication with operators in Dedekind Finite and Stably Finite Rings [PDF]
Messages in communication networks often are considered as "discrete" taking values in some finite alphabet (e.g. a finite field). However, if we want to consider for example communication based on analogue signals, we will have to consider messages that
Riis, S
core

