Results 81 to 90 of about 914,936 (268)

Strict Vector Equilibrium Problems of Multi-Product Supply–Demand Networks with Capacity Constraints and Uncertain Demands

Axioms
This paper considers a multi-product, multi-criteria supply–demand network equilibrium model with capacity constraints and uncertain demands. Strict network equilibrium principles are proposed both in the case of a single criterion and multi-criteria ...
Ru Li, Guolin Yu
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cross-Layer Designs in Coded Wireless Fading Networks with Multicast

, 2010
A cross-layer design along with an optimal resource allocation framework is formulated for wireless fading networks, where the nodes are allowed to perform network coding.
Gatsis, Nikolaos, Giannakis, Georgios B., Rajawat, Ketan   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multilayer Network-Based Evaluation of the Efficiency and Resilience of Network Flows

Complexity
Supply chain optimization and resource allocation are challenging because of the complex dynamics of flows. We can classify these flows based on whether they perform value-added or nonvalue-added activities in our process.
András Rácz-Szabó, Tamás Ruppert, János Abonyi   +2 more
doaj   +1 more source

Incorporating Transportation Network Structure in Spatial Econometric Models of Commodity Flows [PDF]

We introduce a regression-based gravity model for commodity flows between 35 regions in Austria. We incorporate information regarding the highway network into the spatial connectivity structure of the spatial autoregressive econometric model.
LeSage, James P., Polasek, Wolfgang
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A Simplified Network Model for Travel Time Reliability Analysis in a Road Network

Journal of Advanced Transportation, 2017
This paper proposes a simplified network model which analyzes travel time reliability in a road network. A risk-averse driver is assumed in the simplified model.
Kenetsu Uchida, Teppei Kato
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Creating the N-Form Corporation as a Managerial Competence [PDF]

This paper discusses key properties of the N-form corporation or internal network forms of organizing from three mutually related perspectives: structure, knowledge flows and management processes.
Bosch, F.A.J. van den, Wijk, R.A.J.L. van   +1 more
core   +1 more source