E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The determinants of co-inventor tie formation: proximity and network dynamics [PDF]
This paper investigates the determinants of co-inventor tie formation using micro-data on genomic patents from 1990 to 2006 in France. We consider in a single analysis the relational and proximity perspectives that are usually treated separately.
Anne Plunket, Lorenzo Cassi
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Exploring the Role of Artificial Intelligence in Precision Photonics: A Case Study on Deep Neural Network‐Based fs Laser Pulsed Parameter Estimation for MoOx Formation [PDF]
Jose R. Paredes‐Miguel +6 more
openalex +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Dynamics of Interfirm Networks along the Industry Life Cycle: The Case of the Global Video Games Industry 1987-2007 [PDF]
In this paper, we study the formation of network ties between firms along the life cycle of a creative industry. We focus on three drivers of network formation: i) network endogeneity which stresses a path-dependent change originating from previous ...
Mathijs de Vaan +2 more
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Discrete Fracture Network and Fractured Reservoir Characterization in Khabaz Field-Tertiary Formation [PDF]
, 2019 Adnan Ajam Abed, Sammera H. Mohammed
openalex +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Costly Network Formation and Regular Equilibria [PDF]
We prove that for generic network-formation games where players incur some strictly positive cost to propose links the number of Nash equilibria is finite.
Carlos Pimienta, Francesco De Sinopoli
core
Ising-PageRank model of opinion formation on social networks
, 2019 Klaus M. Frahm, Dima L. Shepelyansky
openalex +2 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source