Results 131 to 140 of about 13,123,772 (306)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Facteurs associés à l’hésitation vaccinale dans la Région Maritime au Togo en 2023: étude transversale

Journal of Interventional Epidemiology and Public Health
Introduction: La vaccination des enfants est une intervention de santé publique efficace pour prévenir les maladies et diminuer les morbidités. Elle est de nos jours menacée par une hésitation entrainant une baisse des couvertures vaccinales de 2019 à ...
Kokou Ayamekpe, Mandjaréou Assih, Takpaya Gnaro, Yao Kata, Yamdi Kanou, Ali Napo, Titaféi Pouwe Tare, Assiongbonvi Kangny-Zovoin, Atèhèzi Adom, Koffi Akolly, Rébecca Méyè Kinde, Didier Koumavi Ekouevi   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Long-term associations between physical activity during adolescence and health in early adulthood: a systematic review

Frontiers in Adolescent Medicine
BackgroundDespite the recent surge in cohort studies examining the long-term effects of physical activity (PA) during adolescence on health in adulthood, no recent literature review summarizes this relationship.
Pierre Philippe Wilson Registe, Pierre Philippe Wilson Registe, Sophie Black, François Gallant, François Gallant, Pamela Tanguay, Pamela Tanguay, Daniel Saucier, Daniel Saucier, Pierre Faivre, Pierre Faivre, Saïd Mekari, Saïd Mekari, Mathieu Bélanger, Mathieu Bélanger, Mathieu Bélanger   +15 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Identification of distinct physical activity profiles through adolescence: a longitudinal qualitative description study

Frontiers in Sports and Active Living
IntroductionWe aimed to better understand longitudinal physical activity experiences among initially active adolescents and to identify and describe distinct physical activity profiles.MethodsA sample of 23 physically active participants [52% female ...
Mathieu Bélanger, Mathieu Bélanger, Mathieu Bélanger, Julie Goguen, Jacinthe Beauchamp, Jacinthe Beauchamp, François Gallant, François Gallant, Anika Boucher, Anika Boucher, Jean-Sébastien Chevarie, Jean-Sébastien Chevarie, Sara DeGrâce, Sara DeGrâce, Yanis Saheb, Yanis Saheb, Maryse Gagnon, Maryse Gagnon, Isabelle Doré, Isabelle Doré, Catherine M. Sabiston   +20 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source