Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Politics and Social Partnership - Flexible Network Governance [PDF]
This paper reassesses the relationship between social partnership and the broader Irish policy process. What has developed may be conceptualised as “flexible network governance”.
Niamh Hardiman
core
The Shape of Watershed Governance: Locating the Boundaries of Multiplex Networks
, 2015 Governance networks are both nested and interconnected systems. Identifying internal boundaries within governance networks, such as those governance structures that influence and are influenced by large and diverse watersheds such as the Lake Champlain ...
Zia, Asim +4 more
core +1 more source
Network of Networks: Preliminary Lessons from the Antwerp Port Authority on Crisis Management and Network Governance to Deal with the COVID-19 Pandemic. [PDF]
Public Adm Rev, 2020 van den Oord S +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Ocean governance: the New Zealand dimension [PDF]
, 2012 The Oceans Governance project was funded by the Emerging Issues Programme, overseen by the Institute of Policy Studies at Victoria University of Wellington. Its primary goal is to provide interested members of the public and policymakers with a
Michael Vincent McGinnis
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
"European Governance – Negotiation and Competition in the Shadow of Hierarchy" [PDF]
, 2007 This paper argues that the EU is not as unique a governance system as the Babylonian variety of its labels may suggest. Like its member states, the EU features a combination of different forms of governance that cover the entire range between market and ...
Borzel, Tanja A.
core
A Model for Tax Evasion Prevention in Iran, Based on Preventive Network Governance Approach [PDF]
فرایند مدیریت و توسعهPurpose: The purpose of this article was to present a preventive network governance model to meet tax evasion as a case study in Tax Affairs Organization of the Islamic Republic of Iran. Methodology: The statistical sample, consisting of thirty managers
Reza Khodabandeh +2 more
doaj
Geolocation data of irrigation network in water user association's operation area under community-based and provider-based network governance. [PDF]
Data Brief, 2020 Khasan AF, Rondhi M, Mori Y, Kondo T.
europepmc +1 more source