Results 101 to 110 of about 7,468,732 (318)
Scatter Search Applied to the Inference of a Development Gene Network
Computation, 2017 Efficient network inference is one of the challenges of current-day biology. Its application to the study of development has seen noteworthy success, yet a multicellular context, tissue growth, and cellular rearrangements impose additional computational ...
Amir Masoud Abdol +3 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Network-inference-based prediction of the COVID-19 epidemic outbreak in the Chinese province Hubei
Applied Network Science, 2020 At the moment of writing, the future evolution of the COVID-19 epidemic is unclear. Predictions of the further course of the epidemic are decisive to deploy targeted disease control measures.
B. Prasse +3 more
semanticscholar +1 more source
Neural networks for inference, inference for neural networks
, 2018 Bayesian statistics is a powerful framework for modeling the world and reasoning over uncertainty. It provides a principled method for representing our prior knowledge, and updating that knowledge in the light of new information. Traditional Bayesian statistics, however, has been limited to simple models.
openaire +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network
Molecular Systems Biology, 2015 Organisms from all domains of life use gene regulation networks to control cell growth, identity, function, and responses to environmental challenges. Although accurate global regulatory models would provide critical evolutionary and functional insights,
Mario L Arrieta‐Ortiz +17 more
doaj +1 more source
Inference of Ecological Interaction Networks [PDF]
Annales Zoologici Fennici, 2008 To appear in Annales Zoologici ...
Vera-Licona, Paola +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Inference of gene regulation functions from dynamic transcriptome data
eLife, 2016 To quantify gene regulation, a function is required that relates transcription factor binding to DNA (input) to the rate of mRNA synthesis from a target gene (output).
Patrick Hillenbrand +3 more
doaj +1 more source