Results 111 to 120 of about 5,161,693 (301)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Differentiation of Residents’ Cultural Consumption Tendency and Consumption Recommendation System Based on Network Inference Algorithm

Foundations of Computing and Decision Sciences
To address the issue of insufficient accuracy in consumer recommendation systems, a new biased network inference algorithm is proposed based on traditional network inference algorithms.
Lian Naiyu, Xu Hengzhe, Zhang Feiyang
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

GeneSPIDER – gene regulatory network inference benchmarking with controlled network and data properties

, 2017
A key question in network inference, that has not been properly answered, is what accuracy can be expected for a given biological dataset and inference method.
Sonnhammer, Erik L. L.,, Daniel C. Morgan, Studham, Matthew,, Torbjörn E. M. Nordling, Andreas Tjärnberg, Erik L. L. Sonnhammer, Tjärnberg, Andreas,, Nordling, Torbjörn E. M., Morgan, Daniel C.,, Matthew Studham, Nordling, Torbjörn E. M.,   +10 more
core   +1 more source

Deep Learning Approach To Gene Network Inference [PDF]

, 2023
Gene regulatory network(GRN) inference remains a challenging problem in the field of bioinformatics. GRN contain valuable information needed to get a deeper understanding of the regulatory network. This could lead to advances in disease treatment or help
Johannessen, Daniel Hammerstad
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Monthly rainfall time series prediction using modular fuzzy inference system with nonlinear optimization techniques [PDF]

, 2012
Accurate rainfall time series prediction is one of the important tasks in hydrological study. A conventional time series model such as autoregressive moving average or an intelligent model such as artificial neural network have been used efficiently to ...
Kajornrit, J.
core  

Network delay inference from additive metrics [PDF]

, 2010
We use computational phylogenetic techniques to solve a central problem in inferential network monitoring. More precisely, we design a novel algorithm for multicast-based delay inference, that is, the problem of reconstructing delay characteristics of a ...
Rajagopal, Ram, Roch, Sébastien, Bhamidi, Shankar   +2 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source