Results 101 to 110 of about 5,161,693 (301)

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, 2018
The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration.
Raphaelle Lesage, Raphaelle Lesage, Johan Kerkhofs, Johan Kerkhofs, Liesbet Geris, Liesbet Geris, Liesbet Geris   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Psychometric network inference: A comparative analysis

Recently, network-based approaches have provided an important contribution for the understanding of mental disorders. A growing number of statistical models, developed in the context of continuous variables in high-dimensional settings, are currently ...
Delli Colli, Claudia, Claudia Delli Colli, Giuseppe F. Italiano, Italiano, Giuseppe, F., Catherine MATIAS, Branchi, Igor, Matias, Catherine, Igor Branchi, Sinaimeri, Blerina, Blerina Sinaimeri   +9 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development

Frontiers in Physiology, 2018
Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks
Sophie Koszinowski, Sophie Koszinowski, Veronica La Padula, Veronica La Padula, Frank Edlich, Kerstin Krieglstein, Hauke Busch, Hauke Busch, Hauke Busch, Melanie Boerries, Melanie Boerries, Melanie Boerries   +11 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

sabinaHSBM: An R package for link prediction and network reconstruction using hierarchical stochastic block models

Methods in Ecology and Evolution
Network analysis is a powerful framework for investigating complex systems across disciplines, including ecology. However, ecological network data are often incomplete or error‐prone due to sampling limitations, detection failures and taxonomic ...
Herlander Lima, Jennifer Morales‐Barbero, Rubén G. Mateo, Ignacio Morales‐Castilla, Miguel Á. Rodríguez   +4 more
doaj   +1 more source

Scatter Search Applied to the Inference of a Development Gene Network

Computation, 2017
Efficient network inference is one of the challenges of current-day biology. Its application to the study of development has seen noteworthy success, yet a multicellular context, tissue growth, and cellular rearrangements impose additional computational ...
Amir Masoud Abdol, Damjan Cicin-Sain, Jaap A. Kaandorp, Anton Crombach   +3 more
doaj   +1 more source