Results 71 to 80 of about 166,926 (313)
Quantifying the Variability in Resting-State Networks
Entropy, 2019 Recent precision functional mapping of individual human brains has shown that individual brain organization is qualitatively different from group average estimates and that individuals exhibit distinct brain network topologies.
Isaura Oliver +3 more
doaj +1 more source
Inferring signalling networks from images
Journal of Microscopy, 2013 SummaryThe mapping of signalling networks is one of biology's most important goals. However, given their size, complexity and dynamic nature, obtaining comprehensive descriptions of these networks has proven extremely challenging. A fast and cost‐effective means to infer connectivity between genes on a systems‐level is by quantifying the similarity ...
Evans, L +3 more
openaire +2 more sources
Quantum inference on Bayesian networks [PDF]
Physical Review A, 2014 Performing exact inference on Bayesian networks is known to be #P-hard. Typically approximate inference techniques are used instead to sample from the distribution on query variables given the values $e$ of evidence variables. Classically, a single unbiased sample is obtained from a Bayesian network on $n$ variables with at most $m$ parents per node in
Low, Guang Hao +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Generalized Preference Learning for Trust Network Inference
IEEE Access, 2019 Trust inference is essential in a plethora of data mining and machine learning applications. Unfortunately, conventional approaches to trust inference assume trust networks are available, while in practice they must be derived from social network ...
Domenico Mandaglio, Andrea Tagarelli
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
A Novel Data-Driven Boolean Model for Genetic Regulatory Networks
Frontiers in Physiology, 2018 A Boolean model is a simple, discrete and dynamic model without the need to consider the effects at the intermediate levels. However, little effort has been made into constructing activation, inhibition, and protein decay networks, which could indicate ...
Leshi Chen +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Network Localization of Fatigue in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source