Results 41 to 50 of about 771,995 (268)
Yearbook of Swiss Administrative Sciences, 2013 This paper explores the role that Government should play when networks are established for the provision of public services. Should Government leave and give overall autonomy to the networked organizations?
Daniela Cristofoli, Laura Maccio’
doaj +1 more source
Network tie structure causing OSS group innovation and growth [PDF]
Problems and Perspectives in Management, 2017 Open source software (OSS) development as an inexpensive process to develop software threatens proprietary software business strategies. Providing business strategy to benefit from volunteer developers for the purpose of contributing to existing projects,
Stefan Kambiz Behfar +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Network Anomaly Prediction Method Based on Big Data
Dianxin kexue, 2014 With the development of the network technology and expansion of the network size,the probability of network anomaly is greatly increased,which makes network management face greater challenges.An important task of network management is network anomaly ...
Xu Cao, Ruitong Cao
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Managed clinical networks [PDF]
Archives of Disease in Childhood, 2002 Multilateral collaboration as a basis for the future organisation of paediatric services? The NHS plan1 opened by affirming the value placed on the NHS, while also casting a warning shadow: “The NHS is the public service most valued by British people . . .
S, Cropper, A, Hopper, S A, Spencer
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source