Results 71 to 80 of about 2,335,375 (238)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Research on the modeling of the Internet delay space
Tongxin xuebao, 2012 Firstly,the concept of the modeling of the Internet delay space was presented,and then various delay models were analyzed from the evolvement view.In the following section,the challenges of Internet delay space modeling were pointed out.Finally,the ...
Zhan-feng WANG +4 more
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Power Transformer Diagnostics, Monitoring and Design Features
Energies, 2018 The reliability of the power grid system directly contributes to the economic well-being and the quality of life of citizens in any country. [...]
Issouf Fofana, Yazid Hadjadj
doaj +1 more source
A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement. [PDF]
Biomater Res, 2022 Han X +7 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Study on network performance evaluation method based on measurement
Tongxin xuebao, 2006 In order to evaluate the condition of network,a new synthetically multi-metric performance evaluation method was put forward based on multiple measurement metrics and applied to the performance evaluation of links and nets.The value of calculation ...
ZHANG Dong-yan +2 more
doaj
Bond Wire Damage Detection Method on Discrete MOSFETs Based on Two-Port Network Measurement. [PDF]
Micromachines (Basel), 2022 Yun M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source