Results 51 to 60 of about 334,296 (248)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Simultaneous routing and flow rate optimization in energy–aware computer networks
International Journal of Applied Mathematics and Computer Science, 2016 The issue of energy-aware traffic engineering has become prominent in telecommunications industry in the last years. This paper presents a two-criteria network optimization problem, in which routing and bandwidth allocation are determined jointly, so as ...
Jaskóła Przemysław +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Optimization in telecommunication networks [PDF]
Statistica Neerlandica, 2005 Network design and network synthesis have been the classical optimization problems in telecommunication for a long time. In the recent past, there have been many technological developments such as digitization of information, optical networks, Internet, and wireless networks. These developments have led to a series of new optimization problems.
openaire +4 more sources
Computing optimal shortcuts for networks [PDF]
European Journal of Operational Research, 2019 We study augmenting a plane Euclidean network with a segment, called a shortcut, to minimize the largest distance between any two points along the edges of the resulting network. Problems of this type have received considerable attention recently, mostly for discrete variants of the problem.
Delia Garijo +3 more
openaire +12 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Network Optimization Algorithm Based on Power Control and Channel Assignment
Dianxin kexue, 2015 WLAN has been massively deployed in various places.However，the poor user perception of network quality，or even dropping line，unable to connect to the network and other issues.For this case，a network optimization algorithm based on power control and ...
Yue Liu, Xiaolei Guo, Xun Zhang
doaj
A novel Direct Small World network model
上海师范大学学报. 自然科学版, 2016 There is a certain degree of redundancy and low efficiency of existing computer networks.This paper presents a novel Direct Small World network model in order to optimize networks.In this model,several nodes construct a regular network.Then,randomly ...
LIN Tao +4 more
doaj +1 more source
Research on the application of search algorithm in computer communication network
Journal of Intelligent Systems, 2022 This article mitigates the challenges of previously reported literature by reducing the operating cost and improving the performance of network. A genetic algorithm-based tabu search methodology is proposed to solve the link capacity and traffic ...
Ai Hua +4 more
doaj +1 more source