Results 71 to 80 of about 6,931,246 (294)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Performance Analysis of Congestion Control Mechanism in Software Defined Network (SDN)

open access: yesMATEC Web of Conferences, 2017
In the near future, the traditional networks architecture will be difficult to be managed. Hence, Software Defined Network (SDN) will be an alternative in the future of programmable networks to replace the conventional network architecture. The main idea
Rahman M. Z. A.   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Analysis of packet loss rate based on the measured traffic

open access: yesTongxin xuebao, 2013
The packet loss rate is one of key indicators to evaluate the performance of network.A method for calculating packet loss rate in the measured data based on the intact TCP flows was presented.Based on the measured data,the packet loss rate of Jiangsu ...
Ting MI, Wei DING
doaj   +2 more sources

A constant-time chunking algorithm for packet-level deduplication

open access: yesICT Express, 2019
Redundancy elimination or deduplication over network packets requires significant computing resources to find basic units of repeated contents, called chunks, by checking every byte in every packet.
MyungKeun Yoon
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Research to Avoid the Energy Hole Problem in the Wireless Sensor Network that Different Data Generation Rate in Different Regional

open access: yesDianxin kexue, 2013
The energy hole problem that different data generation rate in different regional in wireless sensor network was studied, using ring network model. Based on this, two kinds of mechanism were defined, which are the data transmitted in the same ring but ...
Mingsheng Liu, Sen Miao, Yan Li
doaj   +2 more sources

Home - About - Disclaimer - Privacy