Results 261 to 270 of about 337,823 (305)
Some of the next articles are maybe not open access.
Common Network Pharmacology Software
2021As a growing trend in current pharmacology research and an important medical application in network science research, network pharmacology has become an indispensable complement to traditional pharmacology research with the immense accumulation and integration of large-scale pharmacology and disease molecular network data.
Xuezhong Zhou, Ning Wang, Xing Zhai
openaire +1 more source
Network Pharmacology of Glioblastoma
Current Drug Discovery Technologies, 2013With increasing knowledge of cellular networks of gene and molecular interactions, and their alterations in GBM (glioblastoma multiforme), it is now possible to apply methods of Network Pharmacology (NP) to predict candidate drug targets for this malignant brain tumor.
openaire +2 more sources
Network Pharmacology: Reigning in Drug Attrition?
Current Drug Discovery Technologies, 2013In the process of drug development, there has been an exceptionally high attrition rate in oncological compounds entering late phases of testing. This has seen a concurrent reduction in approved NCEs (new chemical entities) reaching patients. Network pharmacology has become a valuable tool in understanding the fine details of drug-target interactions ...
Osama M, Alian +3 more
openaire +2 more sources
Network Pharmacology and Epilepsy
2016Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas.
openaire +2 more sources
Network pharmacological mechanism of Cinobufotalin against glioma
2021Cinobufotalin was extracted from the skin of Chinese giant salamander or black sable with good clinical effect against tumor. This study aims to explore the mechanism of Cinobufotalin components and predict the target of action of Cinobufotalin on glioma.The active components of Cinobufotalin were screened by the Chinese medicine pharmacology database ...
Cong, Li +9 more
openaire +2 more sources
Network Pharmacology: Exploring the Resources and Methodologies
Current Topics in Medicinal Chemistry, 2018Multi-target and combinatorial therapies have been focused for the past several decades. These approaches achieved considerable therapeutic efficacy by modulating the activities of the targets in complex diseases such as HIV-1 infection, cancer and diabetes disease.
Junaid, Muhammad +6 more
openaire +2 more sources
Editorial: Network pharmacology and AI
Journal of Ethnopharmacology, 2023Shao, Li +3 more
openaire +2 more sources
Rectifying Cancer Drug Discovery Through Network Pharmacology
Future Medicinal Chemistry, 2014In spite of the expensive preclinical testing, the consistent failure to translate many promising targeted drugs from the laboratory bench to the clinic raises the question of whether the single-pathway drug-discovery strategies offer the correct perspective.
Asfar S, Azmi, Ramzi M, Mohammad
openaire +2 more sources
Standardized Drug and Pharmacological Class Network Construction
2013Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we
Qian, Zhu +3 more
openaire +2 more sources
[Network pharmacology and drug discovery].
Sheng li ke xue jin zhan [Progress in physiology], 2013The pharmaceutical industry has historically relied on particular families of 'druggable' proteins against which to develop compounds with desired actions. But proteins rarely function in isolation in and outside the cell; rather, proteins operate as part of highly interconnected cellular networks.
Juan, Wang, Xue-jun, Li
openaire +1 more source