Results 261 to 270 of about 7,014,814 (396)

Network pharmacology-based insights into the role of gut microbiota metabolites in insulin resistance. [PDF]

Front Microbiol
Xiao B, Chen X, Zong R, Guan Y, Zhu Z, Bi S.   +5 more
europepmc   +1 more source

Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of <i>Pterocephalus hookeri</i>

, 2018
Ce Tang, Hai-Jiao Li, Gang Fan, Tingting Kuang, Xianli Meng, Zhong‐Mei Zou, Yi Zhang   +6 more
openalex   +2 more sources

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Integrating network pharmacology and experimental validation to explore the mechanism of Yiqi Ziyin in treating immune thrombocytopenia. [PDF]

Sci Rep
Wang J, Wang B, Zhang Y, Wu LQ.
europepmc   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Berberine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice and Regulates the PI3K-AKT Pathway: A Network Pharmacology Study. [PDF]

J Cell Mol Med
Li X, Meng S, Liu J, Sun M, Zhou M, Ji F, Hong Y.   +6 more
europepmc   +1 more source

A Network Pharmacology Approach to Uncover the Potential Mechanism of Yinchensini Decoction

, 2018
Guoming Chen, Chuyao Huang, Yunyun Liu, Tengyu Chen, Ruilan Huang, Miaozhen Liang, Jie Zhang, Hua Xu   +7 more
openalex   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Phytochemical profiling and network pharmacology-based prediction of Pelargonium graveolens essential oil in the context of Guillain-Barré syndrome. [PDF]

Sci Rep
Haikal A, Hamdi A, Almatary AM.
europepmc   +1 more source

Identifying the Antiproliferative Effect of Astragalus Polysaccharides on Breast Cancer: Coupling Network Pharmacology With Targetable Screening From the Cancer Genome Atlas [PDF]

, 2019
Cun Liu, Huayao Li, Kejia Wang, Jing Zhuang, Fuhao Chu, Chundi Gao, Lijuan Liu, Fubin Feng, Chao Zhou, Wenfeng Zhang, Changgang Sun   +10 more
openalex   +1 more source