Results 261 to 270 of about 628,285 (376)

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Network pharmacology study on the mechanism of Curcumae Rhizoma in the treatment of non-small cell lung cancer. [PDF]

Medicine (Baltimore)
Yang Z, Wu M, Zhou X, Luo J, Liu Y, Li L.   +5 more
europepmc   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma. [PDF]

Bioresour Bioprocess
Yu Q, Zhu L, Ding X, Lou Y.
europepmc   +1 more source

Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of <i>Pterocephalus hookeri</i>

, 2018
Ce Tang, Hai-Jiao Li, Gang Fan, Tingting Kuang, Xianli Meng, Zhong‐Mei Zou, Yi Zhang   +6 more
openalex   +2 more sources

Network pharmacology-based assessment to elucidate the molecular mechanism of anti-diabetic action of Tinospora cordifolia [PDF]

, 2019
Pukar Khanal, B. M. Patil, Bijendra K. Mandar, Yadu Nandan Dey, Taaza Duyu   +4 more
openalex   +1 more source

Applications of Artificial Intelligence in Drug Repurposing

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Artificial intelligence algorithms are transforming drug repurposing by revealing new therapeutic targets and mechanisms. This review highlights the integration of AI frameworks, multimodal datasets, and advanced optimization methods, accelerating the discovery of new indications for existing drugs.
Zhaoman Wan, Xinran Sun, Yi Li, Tianyao Chu, Xueyu Hao, Yang Cao, Peng Zhang   +6 more
wiley   +1 more source

Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis. [PDF]

Front Pharmacol
Wen CQ, Zou J, Li JX, Wang FJ, Ge HT.
europepmc   +1 more source

Network pharmacology: An approach to the analysis of complex systems underlying traditional chinese medicine

, 2018
Shao Li, Hu Y
openalex   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source