Results 241 to 250 of about 339,960 (301)

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke-depression comorbidity. [PDF]

PLoS One
Shu Y, Guo Y, Xu S, He H, Zeng B, Yang Z, Gao W, Li J.   +7 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Unravelling the multi-target mechanism of methoxylated flavonoids in Parkinson's disease: Insights from network pharmacology and molecular dynamics. [PDF]

Toxicol Rep
Ashok C, Jeyabalan S, Pavadai P, M V, S DDP, Mohan D, Sugumar R, Sugumar R, Jabaris SL, Subramaniyan V, Wong LS, Sekar M.   +11 more
europepmc   +1 more source

Integrated metabolomic, nanoformulation, and network pharmacology approach reveals multifunctional bioactivities of an <i>Ocimum sanctum</i> nanoemulsion. [PDF]

Front Bioeng Biotechnol
Mohamed MS, Obidan A, Alfarteesh H, Alsulami SO, Almassabi R, Alqurashi N, Saddeek S, Alsariei RS, Ali AG.   +8 more
europepmc   +1 more source

Integrated Network Pharmacology, Single-Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection. [PDF]

J Cell Mol Med
Wang Z, Zhang H, Xie Z, Xiang Y, Fu Y, Wang Z, Jiao H, Lin N, Niu C, Jiang C, Zheng L.   +10 more
europepmc   +1 more source

Investigating the therapeutic mechanism of Asarum for oral ulcer from a network pharmacology perspective. [PDF]

Medicine (Baltimore)
Zhu X, Zhao M, Zhu H, Wang Y, Lu Y.
europepmc   +1 more source