Results 221 to 230 of about 153,471 (262)

Network-Based Approaches in Pharmacology [PDF]

Molecular Informatics, 2017
AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Olivier Taboureau, Karine Audouze
exaly   +3 more sources

Network Pharmacology: Curing Causal Mechanisms Instead of Treating Symptoms [PDF]

Trends in Pharmacological Sciences, 2022
Para enfermedades complejas, la mayoría de los medicamentos son altamente ineficaces y la tasa de éxito del descubrimiento de fármacos está en constante declive. Si bien la baja calidad, los problemas de reproducibilidad y la irrelevancia traslacional de la mayoría de las investigaciones básicas y preclínicas han contribuido a esto, la actual ...
Cristian Nogales, Christina Kiel, Ana Isabel Casas Guijarro   +2 more
exaly   +4 more sources

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Information Loss in Network Pharmacology

Molecular Informatics, 2019
AbstractWith the advent of increasing computational power and large‐scale data acquisition, network analysis has become an attractive tool to study the organisation of complex systems and the interrelation of their constituent entities in various scientific domains.
Ingo, Vogt, Jordi, Mestres
openaire   +2 more sources

“Network Target” Theory and Network Pharmacology

2021
In the biomedical big data and artificial intelligence era, pioneering interdisciplinary information science research, life science, and medicine are represented by a complex biological network which has attracted increasing attention from researchers.
Shao Li, Qingyang Ding, Xin Wang
openaire   +1 more source

Network Pharmacology of Glioblastoma

Current Drug Discovery Technologies, 2013
With increasing knowledge of cellular networks of gene and molecular interactions, and their alterations in GBM (glioblastoma multiforme), it is now possible to apply methods of Network Pharmacology (NP) to predict candidate drug targets for this malignant brain tumor.
openaire   +2 more sources

Network Pharmacology and Epilepsy

2016
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas.
openaire   +2 more sources

Network Pharmacology: Exploring the Resources and Methodologies

Current Topics in Medicinal Chemistry, 2018
Multi-target and combinatorial therapies have been focused for the past several decades. These approaches achieved considerable therapeutic efficacy by modulating the activities of the targets in complex diseases such as HIV-1 infection, cancer and diabetes disease.
Junaid, Muhammad, Abbas, Khan, Arif, Ali, Li, Fang, Wang, Yanjing, Qin, Xu, Dong-Qing, Wei   +6 more
openaire   +2 more sources

Network Pharmacology: Reigning in Drug Attrition?

Current Drug Discovery Technologies, 2013
In the process of drug development, there has been an exceptionally high attrition rate in oncological compounds entering late phases of testing. This has seen a concurrent reduction in approved NCEs (new chemical entities) reaching patients. Network pharmacology has become a valuable tool in understanding the fine details of drug-target interactions ...
Osama M, Alian, Minjel, Shah, Momin, Mohammad, Ramzi M, Mohammad   +3 more
openaire   +2 more sources

The impact of network biology in pharmacology and toxicology

SAR and QSAR in Environmental Research, 2012
With the need to investigate alternative approaches and emerging technologies in order to increase drug efficacy and reduce adverse drug effects, network biology offers a novel way of approaching drug discovery by considering the effect of a molecule and protein's function in a global physiological environment.
Panagiotou, G.; Taboureau, O.
openaire   +4 more sources

Drug Repositioning Through Network Pharmacology

Current Topics in Medicinal Chemistry, 2016
Low drug productivity has been a significant problem of the pharmaceutical industry for several decades even though numerous novel technologies were introduced during this period. Currently pharmacologic dogma, "single drug, single target, single disease", is at the root of the lack of drug productivity.
Hao, Ye, Jia, Wei, Kailin, Tang, Ritchie, Feuers, Huixiao, Hong   +4 more
openaire   +2 more sources